With a longstanding history of collaborations in education, health services research and community service, Drew University, the only historically black medical school west of the Mississippi River, and UCLA, one of this nation's premier universities, are strategically positioned to establish a multi-disciplinary, collaborative, thematically focused and integrated reproductive science research program aimed at studying the biologic effects of androgens in men and women. The Drew-UCLA Reproductive Science Research Center will augment and strengthen the research infrastructure and research capabilities of faculty and trainees at Drew University by supporting the development of several new translational and clinical research projects deemed to be of high priority and significance because of their relevance to reproductive health of men and women. The objectives of this grant proposal - to develop an integrated research program that serves as the foundation for future expansion in reproductive biology, reproductive endocrinology, and reproductive medicine at Drew - are reflected in the following specific aims: 1). Support the implementation of two reproductive science research projects that effectively use the scientific strengths of our institutions, and promote multi-disciplinary approaches to the specific research topics in the priority areas identified by this RFA; 2) Provide support for two pilot projects to generate data to facilitate the development of innovative hypotheses and studies, and support the efforts of our investigators to generate preliminary data and publications that can help assure their transition to independent funding; 3) Facilitate and formalize new collaborative networks in reproductive science between scientists at Drew University and UCLA; 4) Develop an Administrative and Planning Core to support the scientific projects.
These specific aims will be accomplished by implementing two core research projects and two pilot projects, each having interrelated specific aims consistent with the Center's long-term objectives. The research projects will be supported by an Administrative and Planning Core. The proposed core and pilot projects are inter-linked by a common theme, namely, Biologic Effects of Androgens in Men and Women. Energetic program leadership, cross-disciplinary research projects that are thematically-linked and that evolve logically from our current strengths, enthusiastic commitment of bi-institutional support, a large pool of talented, participating faculty, deep historical roots of our institution in the minority communities, and strong infrastructural support from pre-existing Hormone Assay, Body Composition, RCMI [Research Center for Minority Institution] Molecular Medicine Core, and Exercise Physiology Core laboratories, and University administration, make our institution particularly suitable to benefit from this NICHD initiative. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD041748-05
Application #
7286625
Study Section
Special Emphasis Panel (ZHD1-DRG-D (12))
Program Officer
Tasca, Richard J
Project Start
2003-08-15
Project End
2011-07-31
Budget Start
2007-08-01
Budget End
2011-07-31
Support Year
5
Fiscal Year
2007
Total Cost
$1,312,461
Indirect Cost
Name
Charles R. Drew University of Medicine & Science
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059
Huang, Grace; Pencina, Karol M; Coady, Jeffry A et al. (2015) Functional Voice Testing Detects Early Changes in Vocal Pitch in Women During Testosterone Administration. J Clin Endocrinol Metab 100:2254-60
Huang, G; Wharton, W; Travison, T G et al. (2015) Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial. J Endocrinol Invest 38:455-61
Huang, Grace; Tang, Elizabeth; Aakil, Adam et al. (2014) Testosterone dose-response relationships with cardiovascular risk markers in androgen-deficient women: a randomized, placebo-controlled trial. J Clin Endocrinol Metab 99:E1287-93
Huang, Grace; Basaria, Shehzad; Travison, Thomas G et al. (2014) Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause 21:612-23
Tweed, Jesse Oliver; Hsia, Stanley H; Lutfy, Kabirullah et al. (2012) The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab 23:334-42
Thomson, S; Koren, G; Fraser, L-A et al. (2010) Hair analysis provides a historical record of cortisol levels in Cushing's syndrome. Exp Clin Endocrinol Diabetes 118:133-8
Anghel, A; Jamieson, C A M; Ren, X et al. (2010) Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience 167:554-66
Friedman, T C; Ghods, D E; Shahinian, H K et al. (2010) High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing. Horm Metab Res 42:874-81
Vuong, Cassidy; Van Uum, Stan H M; O'Dell, Laura E et al. (2010) The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 31:98-132
Sánchez, Francisco J; Westefeld, John S; Liu, William Ming et al. (2010) Masculine Gender Role Conflict and Negative Feelings about Being Gay. Prof Psychol Res Pr 41:104-111

Showing the most recent 10 out of 31 publications