The collaborative partnership of Pennsylvania State University (PSU) and Meharry Medical College (MMC) proposes the development of a Cooperative Center for Research in Reproduction at MMC. The proposal addresses two goals. First, the Center will conduct scientifically sound, clinically relevant research in a thematically focused area of gynecologic endocrinology. Specifically, the research development core will study: 1) the role of sex steroid hormones as determinants of bone mineral density score in Black females, 2) the influence of oral contraceptives on the growth of uterine fibroids, and 3) the efficacy and safety of metformin and lifestyle factors in the amelioration of hyperandrogenemia and its associated symptomatology. These studies will generate knowledge and comparisons across race. Secondly, the compelling need to strengthen research infrastructure at a historically Black medical school through development of minority-initiated research proposals, collaboration and mentorship with a research intensive institutional network of experienced investigators, toward the eventual capacity to build an independent clinical research team at MMC will be facilitated. Additionally, core research support resources will be enhanced at MMC.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD044315-03
Application #
6918624
Study Section
Special Emphasis Panel (ZHD1-DRG-D (12))
Program Officer
Tasca, Richard J
Project Start
2003-07-10
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$1,273,929
Indirect Cost
Name
Meharry Medical College
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
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Archibong, Anthony E; Ramesh, Aramandla; Inyang, Frank et al. (2012) Endocrine disruptive actions of inhaled benzo(a)pyrene on ovarian function and fetal survival in fisher F-344 adult rats. Reprod Toxicol 34:635-43
Coney, Ponjola; Demers, Laurence M; Dodson, William C et al. (2012) Determination of vitamin D in relation to body mass index and race in a defined population of black and white women. Int J Gynaecol Obstet 119:21-5
Ladson, Gwinnett; Dodson, William C; Sweet, Stephanie D et al. (2011) Racial influence on the polycystic ovary syndrome phenotype: a black and white case-control study. Fertil Steril 96:224-229.e2
Ladson, Gwinnett; Dodson, William C; Sweet, Stephanie D et al. (2011) The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study. Fertil Steril 95:1059-66.e1-7
Ladson, Gwinnett; Dodson, William C; Sweet, Stephanie D et al. (2011) Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study. Fertil Steril 95:2595-8.e1-6
Sledzi?ska, A; Mielech, A; Krawczyk, B et al. (2011) Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping. BJOG 118:266-9
Ramesh, Aramandla; Archibong, Anthony E; Niaz, Mohammad S (2010) Ovarian susceptibility to benzo[a]pyrene: tissue burden of metabolites and DNA adducts in F-344 rats. J Toxicol Environ Health A 73:1611-25
Sampson, Mariam; Archibong, Anthony E; Powell, Adriane et al. (2010) Perturbation of the developmental potential of preimplantation mouse embryos by hydroxyurea. Int J Environ Res Public Health 7:2033-44
Pawelczyk, Edyta; Nowicki, Bogdan J; Izban, Michael G et al. (2010) Spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer TLR4 receptor on maternal blood monocytes. BMC Pregnancy Childbirth 10:66

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