1. Objectivea. Objective. The Nonhuman Primate Contraceptive Core (NPCC) will provide services and coordination ofanimal usage for U54 Contraceptive Center investigators with approved projects. The NPCC maintains a poolof cynomolgus macaque females and males available for contraceptive (mating) trials in the Division of AnimalResources (DAR), ONPRC; coordinates and performs studies on potential contraceptive agents; takes vaginalswabs to confirm menstruation and insure mating has occurred; performs ultrasounds to monitor forpregnancies; obtains blood samples for hormone assays, pharmacokinetic studies and metabolic profiles. TheCore acclimates the females to a small group (harem) housing situations (10 females to one male) whereinthey can be separated for daily vaginal checks, dosing, blood sampling and ultrasound analyses. In addition,the NPCC trains investigators in established protocols and disseminates information on emerging approaches.The NPCC represents an efficient use of animals and personnel, and provides assistance that is prohibitivelyexpensive to establish in individual investigator's laboratories.
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