The primary objective of the UC Davis MIND Institute IDDRC Neurobehavioral Analysis Core (NAC) is to help investigators generate detailed phenotypic characterizations of individuals with Intellectual and Developmental Disabilities (IDD). Phenotypic characterization requires measures that are appropriate for a representative sample of individuals with IDD and are designed, executed, and analyzed with the most precision and fidelity possible. Existing standardized tests, rating scales, and checklists are often not adequate for such characterization and adaptations of such measures or the creation of new measures are required. Moreover, many measures are often applicable to only a very narrow segment of the IDD population of interest. The NAC will assist IDDRC investigators in ensuring that they have the measures needed to generate advanced biobehavioral characterizations that can stand alone, be used to assess environmental contributions to IDD, or provide the evidence base for the development and evaluation of targeted treatments for IDD. To achieve this objective, the NAC will draw on the interdisciplinary expertise and already developed measures of several MIND Institute and UC Davis faculty and staff to provide key services for investigators conducting neurobiological studies of cognition, emotion, language, and other aspects of brain and behavior in human research participants with neurodevelopmental disorders that create IDD.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD079125-02
Application #
8740544
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$122,509
Indirect Cost
$42,957
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Chen, Chao-Yin; Di Lucente, Jacopo; Lin, Yen-Chu et al. (2018) Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol Dis 109:25-32
Leach, P T; Crawley, J N (2018) Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities. Genes Brain Behav 17:e12452
Bauman, M D; Schumann, C M (2018) Advances in nonhuman primate models of autism: Integrating neuroscience and behavior. Exp Neurol 299:252-265
Matt, Lucas; Kirk, Lyndsey M; Chenaux, George et al. (2018) SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Cell Rep 22:2246-2253
Shin, Hyeong-Moo; Schmidt, Rebecca J; Tancredi, Daniel et al. (2018) Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study. Environ Health 17:85
Ren, Chonghua; Adams, Alexa N; Pyles, Benjamin et al. (2018) In Vivo Applications of Cell-Penetrating Zinc-Finger Transcription Factors. Methods Mol Biol 1867:239-251
Olson, David E (2018) Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics. J Exp Neurosci 12:1179069518800508
Keil, Kimberly P; Miller, Galen W; Chen, Hao et al. (2018) PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol 92:3163-3173
Del Hoyo Soriano, Laura; Thurman, Angela John; Harvey, Danielle Jenine et al. (2018) Genetic and maternal predictors of cognitive and behavioral trajectories in females with fragile X syndrome. J Neurodev Disord 10:22
Coulson, Rochelle L; Yasui, Dag H; Dunaway, Keith W et al. (2018) Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nat Commun 9:1616

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