The primary objective of the UC Davis MIND Institute IDDRC Neurobehavioral Analysis Core (NAC) is to help investigators generate detailed phenotypic characterizations of individuals with Intellectual and Developmental Disabilities (IDD). Phenotypic characterization requires measures that are appropriate for a representative sample of individuals with IDD and are designed, executed, and analyzed with the most precision and fidelity possible. Existing standardized tests, rating scales, and checklists are often not adequate for such characterization and adaptations of such measures or the creation of new measures are required. Moreover, many measures are often applicable to only a very narrow segment of the IDD population of interest. The NAC will assist IDDRC investigators in ensuring that they have the measures needed to generate advanced biobehavioral characterizations that can stand alone, be used to assess environmental contributions to IDD, or provide the evidence base for the development and evaluation of targeted treatments for IDD. To achieve this objective, the NAC will draw on the interdisciplinary expertise and already developed measures of several MIND Institute and UC Davis faculty and staff to provide key services for investigators conducting neurobiological studies of cognition, emotion, language, and other aspects of brain and behavior in human research participants with neurodevelopmental disorders that create IDD.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD079125-02
Application #
8740544
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$122,509
Indirect Cost
$42,957
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Ozonoff, Sally; Li, Deana; Deprey, Lesley et al. (2018) Reliability of parent recall of symptom onset and timing in autism spectrum disorder. Autism 22:891-896
Benyakorn, Songpoom; Calub, Catrina A; Riley, Steven J et al. (2018) Computerized Cognitive Training in Children With Autism and Intellectual Disabilities: Feasibility and Satisfaction Study. JMIR Ment Health 5:e40
Weir, R K; Bauman, M D; Jacobs, B et al. (2018) Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains. J Comp Neurol 526:262-274
Edmiston, Elizabeth; Jones, Karen L; Vu, Tam et al. (2018) Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders. Brain Behav Immun 69:399-407
Gangi, Devon N; Schwichtenberg, A J; Iosif, Ana-Maria et al. (2018) Gaze to faces across interactive contexts in infants at heightened risk for autism. Autism 22:763-768
Pyles, Benjamin; Bailus, Barbara J; O'Geen, Henriette et al. (2018) Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain. Methods Mol Biol 1767:227-239
Shen, Mark D; Nordahl, Christine W; Li, Deana D et al. (2018) Extra-axial cerebrospinal fluid in high-risk and normal-risk children with autism aged 2-4 years: a case-control study. Lancet Psychiatry 5:895-904
Napoli, Eleonora; Schneider, Andrea; Wang, Jun Yi et al. (2018) Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Mol Neurobiol :
CastaƱeda, Alejandro R; Pinkerton, Kent E; Bein, Keith J et al. (2018) Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization. Toxicol Lett 292:85-96

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