Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HG003914-02S1
Application #
7426620
Study Section
Special Emphasis Panel (ZMH1-ERB-Y (02))
Program Officer
Ozenberger, Bradley
Project Start
2005-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$40,250
Indirect Cost
Name
Columbia University (N.Y.)
Department
Physiology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Vidovi?, Dušica; Xie, Yuli; Rinderspacher, Alison et al. (2011) Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype. J Comput Aided Mol Des 25:873-83
Vang, Torkel; Xie, Yuli; Liu, Wallace H et al. (2011) Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids. J Med Chem 54:562-71
Vidovi?, Dusica; Schürer, Stephan C (2009) Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design. J Med Chem 52:6649-59
Rinderspacher, Alison; Cremona, Maria Laura; Liu, Yidong et al. (2009) Potent inhibitors of Huntingtin protein aggregation in a cell-based assay. Bioorg Med Chem Lett 19:1715-7
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Xie, Yuli; Liu, Yidong; Gong, Gangli et al. (2008) Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase. Bioorg Med Chem Lett 18:2840-4
Mayer, Thomas; Jagla, Bernd; Wyler, Michael R et al. (2006) Cell-based assays using primary endothelial cells to study multiple steps in inflammation. Methods Enzymol 414:266-83