The African Collaborative Center for Microbiome and Genomics Research (ACCME) is a multi-country, multi-institutional collaborative research involving the Institutes of Human Virology and Genome Sciences at the University of Maryland; Department of Epidemiology and Public Health, School of Medicine University of Maryland, Baltimore; University of Abuja Teaching Hospital, Abuja, Nigeria and the Centre National d'Appui a la lutte centre la Maladie (CNAM) Mali. The objectives of the Center are to collaborate and implement high impact research programs characterizing the human microbiome and its role in health and disease. Specifically, ACCME links and leverages existing funded research and program activities at the collaborating institutions to study the interaction between vaginal microbiome, host genetic factors and molecular variants of Human Papilloma Virus (HPV) to determine correlates of viral persistence in the causal pathway of cervical cancer, a major cause of preventable mortality on the African continent. Recent studies by the investigative team, employing bacterial culture-independent, clone and sequence approach employing 16S ribosomal RNA (rRNA) gene technologies have documented the complexity of vaginal microbiome and classified consistent microbial groupings termed community state types that open a new window to understanding the role that the vaginal microbiome plays in cervical cancer pathogenesis. In addition to contributing to knowledge about vaginal microbiome, HPV persistence and cervical carcinogenesis, ACCME also develops capacity by training postdoctoral students to become the new generation of African scientific leaders while empowering hundreds of African scientists to conduct research in microbiome and genomics.
The African Collaborative Center for Microbiome and Genomics Research (ACCME) leverages advanced research methods and technologies of the University of Maryland, Baltimore to build capacity, conduct training and research the role of vaginal microbiome in Human Papilloma Virus persistence and cervical carcinogenesis as a paradigmatic example of a high impact public health challenge that affects women's morbidity and mortality.
|Adebamowo, Sally N; Famooto, Ayotunde; Dareng, Eileen O et al. (2018) Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women. J Glob Oncol :1-12|
|Dareng, Eileen O; Adebamowo, Sally N; Eseyin, Olabimpe R et al. (2017) Test-Retest Reliability of Self-Reported Sexual Behavior History in Urbanized Nigerian Women. Front Public Health 5:172|
|Adebamowo, Sally N; Ma, Bing; Zella, Davide et al. (2017) Mycoplasma hominis and Mycoplasma genitalium in the Vaginal Microbiota and Persistent High-Risk Human Papillomavirus Infection. Front Public Health 5:140|
|Adebamowo, Sally N; Dareng, Eileen O; Famooto, Ayotunde O et al. (2017) Cohort Profile: African Collaborative Center for Microbiome and Genomics Research's (ACCME's) Human Papillomavirus (HPV) and Cervical Cancer Study. Int J Epidemiol 46:1745-1745j|
|Adebamowo, Sally N; Tekola-Ayele, Fasil; Adeyemo, Adebowale A et al. (2017) Genomics of Cardiometabolic Disorders in Sub-Saharan Africa. Public Health Genomics 20:9-26|
|Oga, Emmanuel A; Schumaker, Lisa M; Alabi, Biodun Sulyman et al. (2016) Paucity of HPV-Related Head and Neck Cancers (HNC) in Nigeria. PLoS One 11:e0152828|
|Jedy-Agba, E E; Dareng, E O; Adebamowo, S N et al. (2016) The burden of HPV associated cancers in two regions in Nigeria 2012-2014. Cancer Epidemiol 45:91-97|
|Dareng, E O; Ma, B; Famooto, A O et al. (2016) Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women. Epidemiol Infect 144:123-37|
|Odutola, Michael; Jedy-Agba, Elima E; Dareng, Eileen O et al. (2016) Burden of Cancers Attributable to Infectious Agents in Nigeria: 2012-2014. Front Oncol 6:216|
|Isa Modibbo, Fatima; Dareng, Eileen; Bamisaye, Patience et al. (2016) Qualitative study of barriers to cervical cancer screening among Nigerian women. BMJ Open 6:e008533|
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