The goal of the Center for Collaborative Research in Minority Health and Health Disparities (CCRMHD) at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) for the next five years is to contribute to the national infrastructure and the capacity for research in the health sciences by supporting translational studies in health disparities affecting the Puerto Rican population. Toward this end, the CCRMHD proposes the following specific aims: (1) target specific minority health and health disparities areas for development and provide initial funding for research activities to support them; (2) promote the professional development of new faculty and early-stage investigators working on these areas (3) develop an efficient and agile research structure to provide services that will facilitate the conduct of collaborative research in minority health and health disparities and develop long-lasting partnerships with commumity- based organizations. We will leverage current research infrastructure and relationships with community- based organizations and stimulate new collaborations utilizing the resources provided by the RCMI Network (RTRN) and other NIH-supported research and mentoring networks such as the CTSA and NRMN. The CCRMHD will integrate its five components into a cohesive structure to address the proposed specific aims and ensure that research activities focus on minority health and health disparities. The Administrative Core, directed by the PI, will oversee and support all core activities and provide direction at a program level. Special attention will be given to the development of career enhancement activities that will promote minority health and health disparities research. With the assistant of an external evaluator progress of the cores toward achieving goals and outcomes will be monitored and evaluated. Preservation of on-going collaborations and partnerships as well as the development of new ones will also be a priority.The Research Infrastructure Core will provide specialized research services in the areas of informatics, genomics, proteomics, tropical and emerging infectious diseases, and neurogenomics- bioimaging to the research projects supported by the CCRMHD as well as other research projects addressing minority health and health disparities. The Investigator Development Core, by supporting pilot projects, will serve as a focal point for promoting professional development of new faculty and early- stage investigators working on diseases that disproportionately affect the Puerto Rican population. The Community Engagement Core, will target the development of long-term partnerships with commumity organizations and facilitate the dissemination of CCRMHD services and research achievements. Finally, we will support three translational Research Projects conducted covering the areas of basic biomedical, behavioral and clinical research. All research projects address mechanisms and/or develop and evaluate interventions to reduce health disparities relevant to the Puerto Rican population.

Public Health Relevance

The proposed Centre for Collaborative Research in Minority Health and Health Disparities (CCRMHD) at the University of Puerto Rico Medical Sciences Campus builds upon research resources developed under a G12 RCMI grant and an extensive academic/community partnership to address health disparities affecting the Puerto Rican population. Translational research projects in the areas of basic biomedical, behavioral and clinical research, if successful, will provide different and innovative approaches to promote minority health and health disparities research among early career investigators and students, enhance participation of Hispanic patients in genomics studies and provide novel interventions to reduce childhood obesity within and outside Puerto Rico.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54MD007600-31S1
Application #
9620258
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Zhang, Xinzhi
Project Start
1997-09-01
Project End
2022-06-30
Budget Start
2017-09-20
Budget End
2018-06-30
Support Year
31
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
Aker, Amira M; Ferguson, Kelly K; Rosario, Zaira Y et al. (2018) The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environ Res 169:41-51
Alves, Janaina M; Martins, Antonio H; Lameu, Claudiana et al. (2018) Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. Stem Cell Rev :
López, Omar Vélez; Gorantla, Santhi; Segarra, Annabell C et al. (2018) Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine. J Neuroimmune Pharmacol :
Roche-Lima, Abiel; Carrasquillo-Carrión, Kelvin; Gómez-Moreno, Ramón et al. (2018) The Presence of Genotoxic and/or Pro-inflammatory Bacterial Genes in Gut Metagenomic Databases and Their Possible Link With Inflammatory Bowel Diseases. Front Genet 9:116
Colón, Jennifer M; González, Pablo A; Cajigas, Ámbar et al. (2018) Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol 299:109-121
Colón-Cruz, Luis; Kristofco, Lauren; Crooke-Rosado, Jonathan et al. (2018) Alterations of larval photo-dependent swimming responses (PDR): New endpoints for rapid and diagnostic screening of aquatic contamination. Ecotoxicol Environ Saf 147:670-680
Jezzini, Sami H; Merced, Amelia; Blagburn, Jonathan M (2018) Shaking-B misexpression increases the formation of gap junctions but not chemical synapses between auditory sensory neurons and the giant fiber of Drosophila melanogaster. PLoS One 13:e0198710
Crespo, Maria J; Roman, Marie; Matias, Jonathan et al. (2018) Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats. Int J Endocrinol 2018:9790303
Hernandez-Suarez, Dagmar F; Botton, Mariana R; Scott, Stuart A et al. (2018) Pharmacogenetic association study on clopidogrel response in Puerto Rican Hispanics with cardiovascular disease: a novel characterization of a Caribbean population. Pharmgenomics Pers Med 11:95-106
Martínez-Rivera, Freddyson J; Barreto-Estrada, Jennifer L (2018) Reply to: Does High-Frequency Deep Brain Stimulation in Dorsal Regions of the Ventral Striatum Impair Extinction of Morphine-Induced Place Preference? Biol Psychiatry 83:e21

Showing the most recent 10 out of 48 publications