The long-term goal of this proposal is to create a strong Neuroscience Research Program at Hunter College by bringing together a core of Neuroscientists whose research focus is the general theme of """"""""Repairing the Damaged Nervous System"""""""", The planned core of molecular/cellular Neurobiologists will have similar, and highly complimentary interests in such key health-related areas as neuronal death and survival, axonal regeneration and guidance during development, and myelination, during both development and after disease or injury. By developing the theme of nervous system repair, the current Neuroscience strengths at Hunter College will be expanded.
The first aim of the proposal is to strengthen the research of two junior investigators already at Hunter, Dr. Vanya Quinones and Dr. Jesus Angulo, to the point where independent funding can be expected. Released time from teaching will allow these two researchers the time to develop their work and, equally important, to foster their planned collaboration and mentoring with established, well- funded, successful scientists. Through these collaborations, the young investigators will learn not only new techniques but also how to accumulate appropriate preliminary data for an independent proposal. Finally, to assure their research development, internal and external advisory committees will monitor the progress and long-term research goals for these two junior investigators. A key feature of the proposed Neuroscience Program stems from the complementary work between the research proposals of the two junior PIs and one submitted by the PD, Dr. Marie T. Filbin, which will bring two exciting new technologies to Hunter: an animal model of spinal cord regeneration and viral vector delivery of foreign cDNAs to primary cells in culture and in vivo. Funding of this proposal will also establish a seminar series in Neuroscience to foster communication between the Neuroscience Program and outside researchers. A strong Neuroscience Research Program will also (a) present Neuroscience to undergraduates at an early stage in their career to help stimulate their interest in this crucial field and (b) provide a wider choice in Neuroscience for graduate students doing their doctoral research. An integrated Neuroscience Program can generate new ideas, expose researchers to a variety of state-of-the-art techniques, and attract strong post-doctoral fellows. It is anticipated that at least two additional young Neuroscience faculty will be recruited to the Program on the general theme """"""""Repairing the Damaged Nervous System"""""""".

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS041073-05
Application #
6800787
Study Section
Special Emphasis Panel (ZNS1-SRB-L (02))
Program Officer
Jones, Michelle
Project Start
2000-09-30
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2006-08-31
Support Year
5
Fiscal Year
2004
Total Cost
$1,530,593
Indirect Cost
Name
Hunter College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
620127915
City
New York
State
NY
Country
United States
Zip Code
10065
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis 1863:1157-1170
He, Huifang; Deng, Kangwen; Siddiq, Mustafa M et al. (2016) Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5. J Neurosci 36:3079-91
Siddiq, Mustafa M; Hannila, Sari S; Carmel, Jason B et al. (2015) Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem 290:16343-56
Shivers, Kai-Yvonne; Nikolopoulou, Anastasia; Machlovi, Saima Ishaq et al. (2014) PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochim Biophys Acta 1842:1707-19
Huang, Qian; Wang, Hu; Perry, Seth W et al. (2013) Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. J Biol Chem 288:12161-74
Huang, He; Wang, Hu; Figueiredo-Pereira, Maria E (2013) Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys 67:55-66
Hannila, Sari S; Siddiq, Mustafa M; Carmel, Jason B et al. (2013) Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-? signaling protein Smad2. J Neurosci 33:5138-51
Myeku, Natura; Wang, Hu; Figueiredo-Pereira, Maria E (2012) cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. Neurosci Lett 527:126-31
Metcalfe, M J; Huang, Q; Figueiredo-Pereira, M E (2012) Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP. Cell Death Dis 3:e326
Myeku, Natura; Figueiredo-Pereira, Maria E (2011) Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem 286:22426-40

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