This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this project is to explore the potential role of inflammation and oxidative stress in modulating endothelial function among obese African American women. Although the association between obesity and impaired endothelial function is well established, the exact mechanism of this association remains unclear. We will examine the impact of obesity-related inflammation and oxidative stress, on circulating levels of endothelial progenitor cells. Exciting new research in regenerative medicine has identified bone marrowderived endothelial progenitor cells that are involved in vessel repair. Most recently, cardiovascular risk factors have been correlated with decreased numbers of circulating endothelial progenitor cells (EPCs), accelerated EPC apoptosis, impairment of vessel forming capacity and endothelial dysfunction. The proposed study relies on the fact that obesity represents a pre-clinical state of vascular pathology, therefore, it is a unique model that can be used to explore the role of these EPCs in the impairment of endothelial function of obesity. Recognizing the complexity of physiological interactions that determine the ultimate state of the endothelium, we propose to probe the mechanistic basis of the relationships between obesity and endothelial function by incorporating a diet intervention which comprises a nutrient composition that is known to augment antioxidant capacity while providing favorable lipid profiles and glucose tolerance. Long term, this should improve our understanding of the basis for the relationship of obesity to vascular disease and may help in the design of dietary interventions in these high-risk individuals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR022814-02
Application #
7380843
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$154,346
Indirect Cost
Name
Morehouse School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Ofili, Elizabeth O; Pemu, Priscilla E; Quarshie, Alexander et al. (2018) DEMOCRATIZING DISCOVERY HEALTH WITH N=Me. Trans Am Clin Climatol Assoc 129:215-234
Van Dyke, Miriam E; Vaccarino, Viola; Dunbar, Sandra B et al. (2017) Socioeconomic status discrimination and C-reactive protein in African-American and White adults. Psychoneuroendocrinology 82:9-16
Van Dyke, Miriam E; Vaccarino, Viola; Quyyumi, Arshed A et al. (2016) Socioeconomic status discrimination is associated with poor sleep in African-Americans, but not Whites. Soc Sci Med 153:141-7
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Pemu, Priscilla E; Anderson, Leonard; Gee, Beatrice E et al. (2012) Early alterations of the immune transcriptome in cultured progenitor cells from obese African-American women. Obesity (Silver Spring) 20:1481-90
Ofori-Acquah, Solomon F; Buchanan, Iris D; Osunkwo, Ifeyinwa et al. (2012) Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease. Anemia 2012:156598
Morris, Alanna Amyre; Zhao, Liping; Ahmed, Yusuf et al. (2011) Association between depression and inflammation--differences by race and sex: the META-Health study. Psychosom Med 73:462-8
Lapu-Bula, Rigobert; Onwuanyi, Anekwe; Bielo, Marie-Vero et al. (2011) Risk factors for acute non-ST-segment elevation myocardial infarction in a population sample of predominantly African American patients with chest pain and normal coronary arteries. Ethn Dis 21:421-8

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