Our ability to translate new scientific knowledge rapidly into improvements in patient and population health continues to be limited by numerous challenges. The Northwestern University Clinical and Translational Sciences Institute (NUCATS) was launched in 2007 to create a home supporting clinical and translational (C&T) science at Northwestern and beyond. Northwestern University (NU) is a leading national research university affiliated with nationally-renowned clinical partners. NUCATS is nationally recognized as an innovation leader in several key areas of C&T science, pioneering novel and scalable approaches in the areas of preclinical therapeutic development, health and biomedical informatics systems, research networking platforms and training programs to promote multi-disciplinary team science;and creation and leadership of a regional consortium of the three Chicago-area CTSAs to promote community engagement activities and practice-based research. In the present proposal, we describe our second generation institute, NUCATS 2.0. The Mission of NUCATS 2.0 is """"""""Speeding transformative research discoveries to patients and the population."""""""" Our Vision is to transform NUCATS into a national model of a highly integrated academic nexus that continually increases the quality, safety, efficiency and speed of innovative C&T research, by pursuing three Global Aims: 1) To speed translation and improve efficiency by integrating processes and programs that connect researchers with a continuum of resources, training, funding opportunities, and strategic partners;2) To develop and implement innovative systems to identify, evaluate, facilitate and disseminate scientific breakthroughs, and improve the quality, safety and cost-effectiveness of C&T research;and 3) To promote Northwestern's culture of collaboration, innovation and translation through team-building, education, and training to empower the multi-disciplinary translational research teams of tomorrow. NUCATS 2.0 will be an innovative leader driving the rapid translation of life-saving and health promoting scientific discoveries to improv clinical practice and population health.

Public Health Relevance

Scientific breakthroughs that could have a profound impact on improving human health occur every day, but translating those discoveries into medical care has historically been a slow process taking years to decades. The Northwestern University Clinical and Translational Sciences Institute (NUCATS) is focused on speeding ground-breaking research discoveries to patients and the population by connecting scientists with resources, team members, and community partners that will enhance the relevance and impact of their research.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZAI1)
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Wilde, David B
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Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
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Liss, David T; Finch, Emily A; Cooper, Andrew et al. (2018) One-year effects of a group-based lifestyle intervention in adults with type 2 diabetes: A randomized encouragement trial. Diabetes Res Clin Pract 140:36-44
Ackermann, Ronald T (2017) From Programs to Policy and Back Again: The Push and Pull of Realizing Type 2 Diabetes Prevention on a National Scale. Diabetes Care 40:1298-1301
Spring, Bonnie; Pellegrini, Christine A; Pfammatter, Angela et al. (2017) Effects of an abbreviated obesity intervention supported by mobile technology: The ENGAGED randomized clinical trial. Obesity (Silver Spring) 25:1191-1198
Deng, Yun; Zhao, Jian; Sakurai, Daisuke et al. (2016) Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis 75:2007-2013
Liss, David T; Finch, Emily A; Gregory, Dyanna L et al. (2016) Design and participant characteristics for a randomized effectiveness trial of an intensive lifestyle intervention to reduce cardiovascular risk in adults with type 2 diabetes: The I-D-HEALTH study. Contemp Clin Trials 46:114-121
Smith, Lewis J; Kalhan, Ravi; Wise, Robert A et al. (2015) Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial. JAMA 313:2033-43
Starren, Justin B; Winter, Andrew Q; Lloyd-Jones, Donald M (2015) Enabling a Learning Health System through a Unified Enterprise Data Warehouse: The Experience of the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. Clin Transl Sci 8:269-71
Jara, Javier H; Genç, Bar??; Cox, Gregory A et al. (2015) Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cereb Cortex 25:4259-72
Rao, Mitesh B; Turelli, Robert; Ackermann, Ronald T (2014) Linking the community and the emergency department. Health Aff (Millwood) 33:907
Winckler, Eva; Brown, Jen; Lebailly, Susan et al. (2013) A novel program trains community-academic teams to build research and partnership capacity. Clin Transl Sci 6:214-21