The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts interventional and observational clinical trials as well as database analyses addressing important questions concerning cancer prevention, screening, symptom intervention, post-treatment surveillance/survivorship, quality of life and cancer care delivery. We place special emphasis upon issues affecting minority, underserved and elderly patient groups, and upon building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance for Clinical Trials in Oncology (Alliance), one of the five National Clinical Trials Network (NCTN) groups, serves as the coordinating center for the conduct of all NCORP Research Base trials. The Alliance members represent community practices and academic medical centers in approximately equal number, so the results of the trials broadly reflect the actual experience of patients across the United States. In order to improve our understanding of the biological basis of cancer risk and pre-malignant disease, biomarkers that detect pre-symptomatic newly diagnosed or recurrent malignancies, as well as the physiologic mechanisms of cancer-related symptoms and treatment-related toxicities, most of our clinical trials include translational research questions requiring the collection of tumor tissue, premalignant tissue samples, blood, or other human biospecimens. These biospecimens create an invaluable repository for understanding the associations between laboratory and clinical observations. The Alliance NCORP Research Base collaborates broadly with other NCORP Research Bases to enroll patients in trials, conduct translational studies, and share data and biospecimens for pooled analyses. We also collaborate broadly with other NCI-funded investigators and consortia, as well as investigators supported through non-NCI sources. Results of Alliance investigator efforts have resulted in more than 99 abstracts and manuscripts over the past five years, many resulting in significant beneficial changes in clinical practice. The scientific questions answered by the Alliance NCORP Research Base represent meaningful and innovative contributions to biomedical sciences, and can only be addressed through a publicly-funded research network.

Public Health Relevance

Approximately one in three women and one in two men in the United States will be diagnosed with cancer during their lifetime. Research to prevent cancer, detect cancer while it is still curable, improve symptoms related to cancer and its treatment, and enhance cancer care delivery strategies will provide major health and economic benefits for Americans and people around the world.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Clinical Research Cooperative Agreements - Single Project (UG1)
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Special Emphasis Panel (ZCA1-GRB-I (M1))
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Mccaskill-Stevens, Worta J
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Mayo Clinic, Rochester
United States
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Woodard, Terri Lynn; Hoffman, Aubri S; Crocker, Laura C et al. (2018) Pathways: patient-centred decision counselling for women at risk of cancer-related infertility: a protocol for a comparative effectiveness cluster randomised trial. BMJ Open 8:e019994
Lustberg, Maryam B; Orchard, Tonya S; Reinbolt, Raquel et al. (2018) Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain. Breast Cancer Res Treat 167:709-718
Barton, Debra L; Shuster, Lynne T; Dockter, Travis et al. (2018) Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance). Support Care Cancer 26:1335-1343
Parsons, J Kellogg; Pierce, John P; Mohler, James et al. (2018) Men's Eating and Living (MEAL) study (CALGB 70807 [Alliance]): recruitment feasibility and baseline demographics of a randomized trial of diet in men on active surveillance for prostate cancer. BJU Int 121:534-539
Seaman, Aaron T; Dukes, Kimberly; Hoffman, Richard M et al. (2018) The complicated 'Yes': Decision-making processes and receptivity to lung cancer screening among head and neck cancer survivors. Patient Educ Couns 101:1741-1747
Gajra, Ajeet; McCall, Linda; Muss, Hyman B et al. (2018) The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance). J Geriatr Oncol 9:221-227
Sio, Terence T; Atherton, Pamela J; Pederson, Levi D et al. (2018) Daily Lisinopril vs Placebo for Prevention of Chemoradiation-Induced Pulmonary Distress in Patients With Lung Cancer (Alliance MC1221): A Pilot Double-Blind Randomized Trial. Int J Radiat Oncol Biol Phys :
Tallarico, Michael; Foster, Jared C; Seisler, Drew et al. (2018) Frequency and impact of grade three or four toxicities of novel agents on outcomes of older patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma (alliance A151611). J Geriatr Oncol 9:321-328
Barton, Debra L; Sloan, Jeff A; Shuster, Lynne T et al. (2018) Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance). Support Care Cancer 26:643-650
Woyach, Jennifer A; Ruppert, Amy S; Heerema, Nyla A et al. (2018) Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL. N Engl J Med 379:2517-2528

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