Cancer patients overall are at increased risk for developing COVID-19. Both cancer and COVID-19 disproportionately affect minority and underserved populations throughout the country and especially in the Gulf South region of Louisiana and Mississippi. These major health disparities are further magnified in cancer patients living in rural areas and regions of concentrated disadvantage (high poverty). Therefore, there is an urgent need to develop a new Louisiana Cancer-COVID-19 (LA-Cancer-COVID-19 Registry) registry to better understand the impact of the current pandemic on cancer patients in the Gulf South Region. The data obtained will be used to understand how COVID-19 has affected existing cancer health disparities and will prepare us for new national diagnostic and treatment initiatives. The parent grant to this supplement is the Gulf South Minority/Underserved Clinical Trials Network (Gulf South CTN) NCORP. The Gulf South CTN is a partnership between LSU Cancer Center ? New Orleans, Ochsner Clinic Foundation, Mary Bird Perkins Cancer Center and LSU- Feist Weiller Cancer Center in Shreveport. Together they oversee a network of 44 clinical sites that have significantly increased enrollments of cancer patients into clinical trials throughout the region. Approximately 50% of patients enrolled are African American. The Louisiana Tumor Registry (LTR), a SEER registry, is also a partner in the Gulf South CTN. The LTR collects all information on cancer patients in the state and has legislative mandate to access all their biological samples and clinical information. For the purpose of this Supplement, the LTR and the Office of Public Health at the Louisiana Department of Health, that oversees the response to COVID-19, have agreed to build this new registry. Therefore the Specific Aims are: 1) Develop the Louisiana Cancer ? COVID-19 Registry by linking the LTR cancer registry with the Louisiana Department of Health (LDH) COVID-19 registry. 2) Use the data from the new registry to study the effect of COVID-19 on cancer health disparities in Louisiana, and 3) More effectively participate in national clinical and epidemiological studies through the coordinated data collection efforts of the Louisiana Cancer- COVID-19 Registry. The LA-Cancer-COVID-19 Registry will allow us to identify cancer patients who have developed COVID-19 and identify those at high risk for developing the infection and to determine the location of coronavirus ?hot spots?. We will be able to determine how COVID-19 impacts cancer health disparities in different populations and in rural vs urban locations. More importantly the Cancer-COVID19 Registry will better prepare us for a resurgence of COVID-19 or other future pandemics by rapidly deploy being able to deploy diagnostic, treatment or epidemiological trials.

Public Health Relevance

Cancer and COVID-19 disproportionately affect minority/underserved populations in the Gulf South Region. The Gulf South Clinical Trials Network proposes to create the Louisiana Cancer ?COVID-19 Registry to better understand the impact of COVID-19 on cancer patients and cancer health disparities in our region, and better participate in national epidemiological or clinical studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
3UG1CA189854-07S1
Application #
10197649
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Lee, Cecilia H
Project Start
2014-08-01
Project End
2025-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Messing, Edward M; Tangen, Catherine M; Lerner, Seth P et al. (2018) Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial. JAMA 319:1880-1888
Henry, N Lynn; Unger, Joseph M; Schott, Anne F et al. (2018) Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202. J Clin Oncol 36:326-332
Flaig, Thomas W; Plets, Melissa; Hussain, Maha H A et al. (2017) Abiraterone Acetate for Metastatic Prostate Cancer in Patients With Suboptimal Biochemical Response to Hormone Induction. JAMA Oncol 3:e170231
Yao, James C; Guthrie, Katherine A; Moran, Cesar et al. (2017) Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518. J Clin Oncol 35:1695-1703
Danilov, Alexey V; Li, Hongli; Press, Oliver W et al. (2017) Feasibility of interim positron emission tomography (PET)-adapted therapy in HIV-positive patients with advanced Hodgkin lymphoma (HL): a sub-analysis of SWOG S0816 Phase 2 trial. Leuk Lymphoma 58:461-465
Moinpour, Carol M; Unger, Joseph M; Ganz, Patricia A et al. (2017) Seven-year follow-up for energy/vitality outcomes in early stage Hodgkin's disease patients treated with subtotal lymphoid irradiation versus chemotherapy plus radiation: SWOG S9133 and its QOL companion study, S9208. J Cancer Surviv 11:32-40
Heinrich, Michael C; Rankin, Cathryn; Blanke, Charles D et al. (2017) Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033. JAMA Oncol 3:944-952
Durie, Brian G M; Hoering, Antje; Abidi, Muneer H et al. (2017) Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet 389:519-527
Puvvada, Soham D; Li, Hongli; Rimsza, Lisa M et al. (2016) A phase II study of belinostat (PXD101) in relapsed and refractory aggressive B-cell lymphomas: SWOG S0520. Leuk Lymphoma 57:2359-69
Press, Oliver W; Li, Hongli; Schöder, Heiko et al. (2016) US Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816. J Clin Oncol 34:2020-7

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