The SWOG National Cancer Institute (NCI) Community Oncology Research Program (NCORP) Research Base (RB) has established itself as an innovative, collaborative, and integral part of the NCI's publicly funded cooperative group enterprise. The overall mission of the SWOG NCORP RB is to rapidly design, activate and complete biologically-driven, scientifically important, and clinically meaningful studies in cancer prevention, control, and cancer care delivery, in adults, adolescents and young adults with or at risk for cancer, and to improve quality of life and quality of survivorship for those with malignancies. Over the last grant cycle, the SWOG NCORP RB exceeded expectations with regard to scientific productivity, rapid dissemination of results, inclusiveness, faculty and student training, administrative efficiency, novel and complex trial designs, and advancement of and incorporation of the patient voice into all aspects of our work. In particular, the SWOG NCORP RB opens high-impact trials and conducts and completes them efficiently. During the reporting period, we accrued a total of 11,470 patients, of which 9897 (86%) were placed onto SWOG-coordinated studies, and 1573 (14%) were SWOG sites enrolling onto non-SWOG studies. SWOG NCORP institutions provided 45% of the accrual (n=4451) to SWOG-coordinated studies. Our results are widely disseminated and have informed multiple practice symptom management and survivorship guidelines. We published results from a large number of studies conducted during the last two cycles (125 manuscripts; 58 abstracts), with 34% issued in journals with an impact factor > 10. Overall, 96 NCORP site members were represented as authors in 54 NCORP manuscripts and abstracts. Over the next grant cycle, we will continue to expand our administrative and data infrastructure, with initiatives addressing patient reported outcomes, a robust and modern data management and patient reported outcomes core, enhanced engagement with community investigators and non-traditional partners, augmented education and involvement of patient advocates, and new quality initiatives. We will expand our research efforts in healthcare disparities across all committees, and we will collaboratively design, conduct, and accrue to novel and practice changing studies, in order to reduce the burden of cancer

Public Health Relevance

The overall mission of the SWOG National Cancer Institute Community Oncology Research Program Research Base is to rapidly design, activate and complete biologically-driven, scientifically important, and clinically meaningful studies in cancer prevention, control and cancer care delivery in adults, adolescents and young adults with or at risk for cancer, and to improve quality of life and quality of survivorship for those with malignancies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
2UG1CA189974-06
Application #
9772877
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Parker, Bernard W
Project Start
2014-08-01
Project End
2025-07-31
Budget Start
2019-08-23
Budget End
2020-07-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Hershman, Dawn L; Unger, Joseph M; Crew, Katherine D et al. (2018) Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L-Carnitine (SWOG S0715). J Natl Cancer Inst 110:669-676
Chavez-MacGregor, Mariana; Unger, Joseph M; Moseley, Anna et al. (2018) Survival by Hispanic ethnicity among patients with cancer participating in SWOG clinical trials. Cancer 124:1760-1769
Fadelu, Temidayo; Zhang, Sui; Niedzwiecki, Donna et al. (2018) Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance). J Clin Oncol 36:1112-1120
Hershman, Dawn L; Till, Cathee; Shen, Sherry et al. (2018) Association of Cardiovascular Risk Factors With Cardiac Events and Survival Outcomes Among Patients With Breast Cancer Enrolled in SWOG Clinical Trials. J Clin Oncol 36:2710-2717
Unger, Joseph M; Vaidya, Riha; Gore, John L (2018) Key design and analysis principles for quality of life and patient-reported outcomes in clinical trials. Urol Oncol :
Cheng, Ting-Yuan David; Darke, Amy K; Redman, Mary W et al. (2018) Smoking, Sex, and Non-Small Cell Lung Cancer: Steroid Hormone Receptors in Tumor Tissue (S0424). J Natl Cancer Inst 110:734-742
Tang, Li; Platek, Mary E; Yao, Song et al. (2018) Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Carcinogenesis 39:125-133
Shen, Sherry; Unger, Joseph M; Crew, Katherine D et al. (2018) Omega-3 fatty acid use for obese breast cancer patients with aromatase inhibitor-related arthralgia (SWOG S0927). Breast Cancer Res Treat 172:603-610
Lee, Shing M; Hershman, Dawn L; Miao, Jieling et al. (2018) Estimating global treatment toxicity burden from adverse-event data. Cancer 124:858-864
Van Blarigan, Erin L; Fuchs, Charles S; Niedzwiecki, Donna et al. (2018) Marine ?-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev 27:438-445

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