The Division of Neonatal and Developmental Medicine at Stanford submits a competing renewal application to participate in the NICHD Cooperative Multicenter Neonatal Research Network (NRN). The Division and its faculty have a history of innovative basic and clinical research accomplishments in neonatal medicine. This expertise dovetails with the Network's goal of rigorous evaluation of treatment and management strategies through multicenter observational studies and interventional trials. Participating in th NRN since 1991, Stanford has proven to be a strong and highly productive asset, contributing extensively to study design, protocol development, execution, analysis, and dissemination of results. Specific strengths include a large, growing NICU population at two sites (Lucile Packard Children's Hospital and El Camino Hospital) with a total of 10,284 births, 1757 NICU admissions, and 94 beds with racial and ethnic diversity typical of the western US. In addition, a four-hospital network staffed by Stanford faculty and linked to the Johnson Center for Pregnancy and Newborn Services at Packard Children's Hospital ensures a robust referral population for clinical trials. PI, Krisa Van Meurs, and Alternate PI, David Stevenson, are skilled and experienced NRN investigators. Susan Hintz serves as Vice-Chair of follow-up, subcommittee member on seven trials, and has achieved an exceptional follow-up rate over 95%. Committed Stanford investigators originated, led, and/or analyzed five studies during last grant cycle (SUPPORT Neuroimaging study, SUPPORT School age follow-up, Preemie aEEG pilot, Predicting outcomes in HIE using aEEG, and Regional tissue oximetry in preterm infants during red blood cells transfusions). Valerie Chock received an Ancillary Studies in Clinical Trials R01 from NHLBI to fund the regional oximetry study. Stanford had extensive involvement in training with 15 visits to Network sites for aEEG training, and responsibility for SUPPORT NEURO School Age visit training in Scottsdale and Movement ABC gold standard training at Stanford. Faculty engagement is strong; 8 Stanford faculty have 28 subcommittee assignments. In addition, Stanford faculty neuroradiology collaborator Patrick Barnes was the central reader for SUPPORT MRI and Whole Body Hypothermia MRI studies, and Susan Hintz assisted in the development of NICHD MRI scoring system. Stanford faculty (Van Meurs, Wusthoff, Davis and Bonifacio) are central aEEG readers for three aEEG studies. Over the last 5 grant cycles Stanford has demonstrated wide- ranging expertise, exceptional leadership, and strong collaborative abilities that have served the NRN well. One of the greatest strengths Stanford has to offer is our extensive and talented pool of young clinical investigators that will become the clinical research leaders of the future. In summary, the Stanford site has the neonatal and subspecialty faculty, physical space, research resources, professional staff, institutional support and patient population necessary to continue as one of the finest centers participating in the NRN.

Public Health Relevance

Large multicenter studies are needed to conduct clinical research that will improve the care and outcomes for newborns. The NICHD Neonatal Research Network's consortium of academic medical centers provides the neonatal population and faculty expertise necessary to rigorously perform observational studies and interventional trials to advance the field of neonatal-perinatal medicine.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HD027880-27
Application #
9253028
Study Section
Special Emphasis Panel (ZHD1-DSR-A (50)R)
Program Officer
Raju, Tonse N
Project Start
1991-04-01
Project End
2021-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
27
Fiscal Year
2017
Total Cost
$262,927
Indirect Cost
$96,517
Name
Stanford University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Bajaj, Monika; Natarajan, Girija; Shankaran, Seetha et al. (2018) Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants. J Pediatr 195:33-38.e2
Travers, Colm P; Carlo, Waldemar A; McDonald, Scott A et al. (2018) Mortality and pulmonary outcomes of extremely preterm infants exposed to antenatal corticosteroids. Am J Obstet Gynecol 218:130.e1-130.e13
Laptook, Abbot R; Bell, Edward F; Shankaran, Seetha et al. (2018) Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants. J Pediatr 192:53-59.e2
Autmizguine, Julie; Tan, Sylvia; Cohen-Wolkowiez, Michael et al. (2018) Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. Pediatr Infect Dis J 37:923-929
Meyers, J M; Tan, S; Bell, E F et al. (2018) Neurodevelopmental outcomes among extremely premature infants with linear growth restriction. J Perinatol :
Phelps, Dale L; Watterberg, Kristi L; Nolen, Tracy L et al. (2018) Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial. JAMA 320:1649-1658
Pappas, Athina; Adams-Chapman, Ira; Shankaran, Seetha et al. (2018) Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage. JAMA Pediatr 172:32-42
Boghossian, Nansi S; Do, Barbara T; Bell, Edward F et al. (2017) Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infants. Early Hum Dev 113:10-17
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Shankaran, Seetha; Laptook, Abbot R; McDonald, Scott A et al. (2017) Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy. J Pediatr 180:275-278.e2

Showing the most recent 10 out of 54 publications