The Division of Maternal-Fetal Medicine at Brown University/Women & Infants Hospital of Rhode Island (WIH) has a strong commitment to a continued high-level of participation in the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network for the purpose of investigating problems in clinical obstetrics, particularly those related to prevention of preterm birth, low birth weight, and obstetrical and medical complications of pregnancy. We have extensive experience in performing clinical trials in these areas, and a strong, stable, and proven research infrastructure. WIH, with ~8,500 annual births, is one of the largest stand- alone obstetric units in the country. We have been a participating center for the past three 5-year cycles of the MFMU Network. We remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years. Since assuming the Brown/WIH PI position in 2009, Dr. Dwight Rouse, along with Dr. Brenna Hughes as Alternate-PI, has endeavored to make Brown/WIH a Network leader, and has been increasingly successful. In the recently completed Network trial Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial we were tied for 2nd among all Network centers for recruitment, and in the two actively-recruiting Network randomized trials--ARRIVE (A Randomized Trial of Induction Versus Expectant Management) and A Randomized Trial to Prevent Congenital Cytomegalovirus -- we rank 3rd. Dr. Hughes leads the latter as sub-committee PI, i.e., she is the overall Network PI of the trial. This cycle, Brown/WIH investigator Dr. Erika Werner, with the joint mentorship of Drs. Rouse and Hughes, as well as Dr. Donald Coustan, presented as a concept and took through to a fully approved protocol (by a vote of 16-0) her proposal for a Network randomized trial of myo-inositol supplementation to prevent gestational diabetes. This protocol will be considered for prioritization at the next prioritization meeting. She also is a member of the Network Meta-Analysis Working Group. That is, in the current Network cycle, we have gone from being a mediocre center to one that leads in scientific and recruitment contributions. We have an experienced, competent, and enthusiastic research team in place, and are confident that our team can help the MFMU Network reach its fullest potential.

Public Health Relevance

Preterm birth remains a largely intractable problem and results in a huge societal health burden, as do other obstetrical and medical complications of pregnancy. The Division of Maternal-Fetal Medicine at Brown University/Women & Infants Hospital of Rhode Island (WIH), through its continued high-level of participation in the Eunice Kennedy Shriver NICHD MFMU Network, will work toward finding solutions to prematurity and other complications of pregnancy, with a special emphasis on randomized clinical trials, the gold standard for the evaluation of medical therapies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HD040500-21
Application #
9906244
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Signore, Caroline
Project Start
2001-04-03
Project End
2021-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
21
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Tita, Alan T N; Jablonski, Kathleen A; Bailit, Jennifer L et al. (2018) Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 219:296.e1-296.e8
Grobman, William A; Bailit, Jennifer; Sandoval, Grecio et al. (2018) The Association of Decision-to-Incision Time for Cesarean Delivery with Maternal and Neonatal Outcomes. Am J Perinatol 35:247-253
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Kominiarek, Michelle A; Saade, George; Mele, Lisa et al. (2018) Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol 132:875-881
Kominiarek, Michelle A; Smid, Marcela C; Mele, Lisa et al. (2018) Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol 132:1386-1393
Varner, Michael W; Mele, Lisa; Casey, Brian M et al. (2018) Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. J Perinatol 38:1490-1495
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Pasko, Daniel N; McGee, Paula; Grobman, William A et al. (2018) Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol 131:1039-1048

Showing the most recent 10 out of 137 publications