In the United States, there are approximately 4 million births per year and childbirth is the leading indication for hospitalization. Correspondingly, the prevention of adverse obstetric outcomes, including preterm birth and maternal morbidity, is an important goal, and clinical trials and observational studies designed to improve obstetric outcomes are of the utmost importance. The Maternal-Fetal Medicine Units (MFMU) Network, by creating a multi-institutional research infrastructure, is an important mechanism to accomplish this goal effectively. The Northwestern Study Center, through its use of innovative recruitment techniques and study design approaches, has been a productive member of the MFMU Network since 2001, and is composed of two institutions that have worked together in the MFMU Network for over 10 years: Northwestern University and NorthShore University Health System. The two Maternal-Fetal Medicine Divisions of the institutions, in addition, have a long and continuing collaboration on multiple other clinical research studies and trials. In this proposal, we present the application of the Northwestern Study Center to renew its participation in the MFMU Network. Led by a team of experienced clinical researchers (William Grobman, MD, MBA; Alan Peaceman, MD; Mara Dinsmoor, MD, MPH; Gail Mallett, RN), the Northwestern Study Center will continue its significant contributions to the MFMU Network's goals though robust enrollment of socioeconomically diverse patients and the conception and development of novel studies.

Public Health Relevance

Obstetric admissions are the leading cause of hospitalization in the United States, and a significant portion of the obstetric population experiences morbidity that has the potential to adversely affect both women and children immediately as well as for years after birth. Northwestern University, as part of the MFMU Network, will substantively contribute to the large-scale clinical trials and observational studies that are needed to improve obstetric outcomes and thereby enhance public health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HD040512-18
Application #
9234570
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Miodovnik, Menachem
Project Start
2001-04-01
Project End
2021-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
18
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
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