The design of the Collaborative Pediatric Critical Care Research Network (CPCCRN) is to investigate the efficacy of treatment and management strategies to care for critically ill children and understand the basic pathophysiological mechanisms of critical illness. CN has been part of the CPCCRN since its inception as an active and successful enrollment site, a constructive and creative presence in the development of CPCCRN research directions and protocols, and has lead in protocol development. The first goal of this proposal is to renew the participation of Children's National in the CPCCRN and participate in a manner that brings innovative, diverse, and unique skills to the CPCCRN. To achieve this goal, CN has restructured its leadership team to include leading researchers in outcomes research, cardiac critical care, and trauma and critical care. This team is also exceptionally experienced at both collaborating in, and leading multi-site studies. To better utilize the full scope of expertise in the Children's Research Institute, the leadership plan is explicit in its intent to collaboratively and constructively involve this expertise, internally thrugh the CN organizational structure and to the CPCCRN when it is appropriate to offer the expertise. Second, Children's National intends to improve the outcomes of critically ill children by both leading as well as participating in studies of the development of morbidity and mortality. As a demonstration of this commitment and expertise, we have presented the concept proposal The Association of PICU Care-Team Performance with Morbidity and Mortality. This proposal conceptually outlines the framework for answering the question: Can improving ICU care-team performance improve patient outcomes such as morbidity and mortality? The proposal outlines the process for measuring and testing the important components of team performance. It would develop generalizable methodology and reach conclusions that would be applicable to areas of medicine where team- based care is important. The concept proposal also demonstrates the intent to utilize interdisciplinary and network expertise.

Public Health Relevance

The renewal of Children's National in the Collaborative Pediatric Critical Care Research Network (CPCCRN) will enhance the network's ability to investigate the treatments and management strategies to care for critically ill children, and specifically, to measure and improve morbidity and mortality in Pediatric Intensive Care Units. Children's National will bring a leadership team of leading researchers in outcomes research, cardiac critical care, and trauma and critical care. The concept proposal is designed to answer the question, 'Can improving ICU care-team performance improve patient outcomes such as morbidity and mortality?'

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
3UG1HD049981-15S1
Application #
10056132
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Maholmes, Valerie
Project Start
2005-05-01
Project End
2020-11-30
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
15
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Berg, Robert A; Sutton, Robert M; Reeder, Ron W et al. (2018) Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation 137:1784-1795
Sutton, Robert M; Reeder, Ron W; Landis, William et al. (2018) Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes. Resuscitation 130:159-166
Davila, Sam; Halstead, E Scott; Hall, Mark W et al. (2018) Viral DNAemia and Immune Suppression in Pediatric Sepsis. Pediatr Crit Care Med 19:e14-e22
Ahmed, Omar Z; Holubkov, Richard; Michael Dean, J et al. (2018) CHANGE IN FUNCTIONAL STATUS AMONG CHILDREN TREATED IN THE INTENSIVE CARE UNIT AFTER INJURY. J Trauma Acute Care Surg :
Muszynski, Jennifer A; Reeder, Ron W; Hall, Mark W et al. (2018) RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med 46:e552-e559
Dalton, Heidi J; Cashen, Katherine; Reeder, Ron W et al. (2018) Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality. Pediatr Crit Care Med 19:1067-1076
Berger, John T; Villalobos, Michele E; Clark, Amy E et al. (2018) Cognitive Development One Year After Infantile Critical Pertussis. Pediatr Crit Care Med 19:89-97
Basu, Sonali; Holubkov, Richard; Dean, J Michael et al. (2018) PICU Autopsies: Rates, Patient Characteristics, and the Role of the Medical Examiner. Pediatr Crit Care Med 19:1137-1145
Zinter, Matt S; Holubkov, Richard; Steurer, Martina A et al. (2018) Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. Biol Blood Marrow Transplant 24:330-336
Berg, Robert A; Reeder, Ron W; Meert, Kathleen L et al. (2018) End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation 133:173-179

Showing the most recent 10 out of 34 publications