As an established Center with a strong enrollment history, The University of Colorado Denver (UCD) Center is uniquely positioned to continue as an active and valuable participant in the NICHD MFMU Network. The strengths of this proposal include: 1) a solid enrollment track record during our first cycle (rank 6-9 out of 14 centers in current studies), 2) an established team of professional research assistants and research nurses that are now well-versed in MFMU processes and protocols, 3) exceptionally strong departmental and institutional commitments to participate in MFMU research bolstered by excellent departmental grants and contracts, IRB, budget and administrative support, 4) a mature MFM faculty deployed at both the University of Colorado Denver and the Denver Health sites with leadership in conducting large multicenter trials and a comprehensive range of specific clinical strengths, 5) a thirty-year history of collaboration on research projects and clinical care between the obstetricians and neonatologists at the both the University of Colorado and Denver Health sites, and 6) the Department's Basic Research Science division and the Colorado Clinical and Translational Sciences Institute that together have extensive experience with translational research and access to numerous research cores on campus. With combined annual deliveries nearing 7000 from an ethnically and economically diverse population in the intermountain west, our geographic and population attributes are additional and important assets that the Colorado Center brings to the MFMU Network.

Public Health Relevance

The goal of the MFMU Network is to design and conduct clinical trials investigating problems in clinical obstetrics, particularly thos related to prevention of low birth weight, prematurity, and medical problems of pregnancy and to facilitate resolution of these problems through a scientifically rigorous network of clinical research units. The public health will be enhanced by improving the health of pregnant women and their children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HD068282-10
Application #
9901596
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Signore, Caroline
Project Start
2011-04-15
Project End
2021-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Alston, Meredith J; Metz, Torri D; Fothergill, Russell et al. (2017) Factors Influencing Residency Program Selection by Medical Students Pursuing Obstetrics and Gynecology. J Grad Med Educ 9:123-127
Adkins, Katlynn; Allshouse, Amanda A; Metz, Torri D et al. (2017) Impact of aspirin on fetal growth in diabetic pregnancies according to White classification. Am J Obstet Gynecol 217:465.e1-465.e5
Metz, Torri D; Gonzalez, Christina; Allshouse, Amanda A et al. (2017) Influence of Patient-Level Factors on Mode of Delivery among Operative Vaginal Delivery Candidates in Modern Practice. Am J Perinatol 34:974-981
Robison, Elizabeth; Heyborne, Kent; Allshouse, Amanda A et al. (2017) Implementation of a Risk-Based Heparin Protocol for Postpartum Venous Thromboembolism Prevention. Obstet Gynecol 130:262-269
Porreco, Richard P; Heyborne, Kent D (2017) Immunogenesis of preeclampsia: lessons from donor gametes. J Matern Fetal Neonatal Med :1-7
Heyborne, Kent D (2017) A Systematic Review of Intrapartum Fetal Head Compression: What Is the Impact on the Fetal Brain? AJP Rep 7:e79-e85
Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17
Euser, A G; Metz, T D; Allshouse, A A et al. (2016) Low-dose aspirin for pre-eclampsia prevention in twins with elevated human chorionic gonadotropin. J Perinatol 36:601-5

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