Overall Core In phase I of the BUILD initiative, we successfully developed and delivered a three-year multi- component research training program for undergraduates from traditionally underrepresented backgrounds aspiring to careers in biomedical science. Our training model, Enhancing Cross- Disciplinary Infrastructure and Training at Oregon (EXITO), was a collaboration among eleven partner institutions across four states (OR, WA, AK, HI) and three Pacific Island territories (American Samoa, Guam, Northern Marianas Islands). In phase II, EXITO 2.0, we propose to enhance EXITO?s successes, maintaining our collaboration with the nine of the eleven original institutions to achieve the Hallmarks of Success outlined by the BUILD Consortium.
Our specific aims are guided by four principles: Sustainability, Enhancement, Evaluation, and Dissemination. We will 1)Sustain essential components of EXITO at primary and partner institutions beyond the NIH funding period, by embedding and aligning them with ongoing and new institutional structures, programs, and services. We will maintain and improve upon our training program through creation of an Office of Undergraduate Research, an innovative tuition benefit package for low-income students, multi-tiered mentoring, further institutionalizing our novel curriculum, and institutionalizing summer research experiences. Our now-robust partnership with our research-intensive partner, OHSU, has been and will be critical to sustaining our successful model. 2) Enhance established EXITO research training and faculty development interventions through continued refinement and adaptation based on evaluation data and lessons learned. We will maintain and sustain our highly successful pilot project program and work with our primary institution administration at Portland State University, to recruit, hire, and retain diverse faculty who can mentor and nurture students from underrepresented backgrounds. 3) Evaluate all aspects of EXITO program to inform enhancement, sustainability, and dissemination efforts. Last, we will 4) Disseminate the EXITO model across our large and diverse partner network to support dissemination and replication of effective strategies at non-BUILD institutions. We will provide materials, training, and technical support to other institutions to facilitate implementation of EXITO model or components and investigate institutional factors and resources associated with implementation fidelity and effectiveness to enable successful replication. By evaluating, enhancing, and making sustainable our successful research pathway for students, for faculty, for Portland State University and our partner institutions, EXITO 2.0 will help address a critical evidence gap in how to build and retain a diverse biomedical workforce. Page 80 Project Summary/Abstract Contact PD/PI: Crespo, Carlos J

Public Health Relevance

The proposed research builds on the successful work of phase I of the BUILD demonstration project, in which we developed and delivered a three-year multi-component research training program for undergraduates from traditionally underrepresented backgrounds aspiring to careers in biomedical science. Here, we propose to maintain the core elements of our successful model, Enhancing Cross-Disciplinary Infrastructure and Training at Oregon (EXITO) while improving it based on our data from the first four years of funding. We will pursue BUILD EXITO?s goals of promoting diversity in the biomedical research workforce guided by four principles: Sustainability, Enhancement, Evaluation, and Dissemination. In so doing, BUILD EXITO will help address a critical evidence gap in how to build and retain a diverse workforce that can understand and solve the health challenges of our diverse country, while addressing disparities in the make up our biomedical workforce. Page 81 Project Narrative

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
2UL1GM118964-06
Application #
9885222
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Falcon-Morales, Edgardo
Project Start
2014-09-26
Project End
2024-06-30
Budget Start
2019-07-29
Budget End
2020-06-30
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Portland State University
Department
Type
DUNS #
052226800
City
Portland
State
OR
Country
United States
Zip Code
97207
Mantua, Janna; Helms, Steven M; Weymann, Kris B et al. (2018) Sleep Quality and Emotion Regulation Interact to Predict Anxiety in Veterans with PTSD. Behav Neurol 2018:7940832
Akkaya, Munir; Akkaya, Billur; Kim, Ann S et al. (2018) Toll-like receptor 9 antagonizes antibody affinity maturation. Nat Immunol 19:255-266
Graham, Alice M; Rasmussen, Jerod M; Rudolph, Marc D et al. (2018) Maternal Systemic Interleukin-6 During Pregnancy Is Associated With Newborn Amygdala Phenotypes and Subsequent Behavior at 2 Years of Age. Biol Psychiatry 83:109-119
Teutsch, Peyton; Jones, Carolyn E; Kaiser, Mara E et al. (2018) Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD. Behav Neurol 2018:6037015
Richardson, Dawn M; Keller, Thomas E; Wolf, De' Sha S et al. (2017) BUILD EXITO: a multi-level intervention to support diversity in health-focused research. BMC Proc 11:19
Perry, Cynthia K; McCalmont, Jean C; Ward, Judy P et al. (2017) Mujeres Fuertes y Corazones Saludables: adaptation of the StrongWomen -healthy hearts program for rural Latinas using an intervention mapping approach. BMC Public Health 17:982
Keller, Thomas E; Logan, Kay; Lindwall, Jennifer et al. (2017) Peer mentoring for undergraduates in a research-focused diversity initiative. Metrop Univ 28:50-66
Iverson, Eric A; Goodman, David A; Gorchels, Madeline E et al. (2017) Extreme Mutation Tolerance: Nearly Half of the Archaeal Fusellovirus Sulfolobus Spindle-Shaped Virus 1 Genes Are Not Required for Virus Function, Including the Minor Capsid Protein Gene vp3. J Virol 91:
Shiramizu, Bruce; Shambaugh, Vicki; Petrovich, Helen et al. (2016) Leading by Success: Impact of a Clinical and Translational Research Infrastructure Program to Address Health Inequities. J Racial Ethn Health Disparities :