This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. At the University of Kentucky (UK), we have established the Center for Clinical and Translational Science (CCTS) as a home for clinical and translational research. UK is located in Lexington, on the western edge of mid-Appalachia, one ofthe poorest areas ofthe country, where there are unprecedented disparities in disease and mortality. Many of these disparities stem from risky behaviors, such as smoking, drug abuse, and obesity. In this proposal, our overarching goal is to transform the pace, effectiveness, and quality of translational research at UK which will result in better health for the people of mid-Appalachia. Scientific discovery offers the potential for improved care, with community-based research offering a faster impact on health through a better dissemination of optimal medical care. However, scientific discoveries often do not reach the community due to the many difficulties with navigating the complex process of clinical and translational research. In this application, we will capitalize on our strengths in education, basic and clinical sciences, as well as our outstanding programs in practice- and community- based participatory research. These efforts will result in scientific discovery that will impact the health ofthe Appalachian rural community in the near term, and prime the pipeline for the future. To accomplish these goals, UK will form a collaboration with Marshall University, which is 2 hr away in Huntington, WV. In addition, we will form an Appalachian Translational Reseach Network involving not only Marshall, but also the CTSAs at the Ohio State University, University of Cinncinati, Morehead University, and Pikeville School of Osteopathic Medicine. This network will be especially important in the further development of our strong programs in community based participatory research. To help integrate our efforts, we have developed an innovative group of faculty CATalysts, who will build collaborative team science programs backed by generous pilot funding that will target novel ideas at all levels of science. New CCTS programs in """"""""Drug Development"""""""", """"""""Novel Methodologies"""""""", and """"""""Risk-Related Behavior Research"""""""" will capitalize on our strengths, engage investigators with diverse areas of expertise, and will more quickly impact the health of the Appalachian community. We have recently recruited a new leader in Biomedical Informatics and have invested heavily in this program, which will greatly improve our ability to transform data into knowledge throughout the CCTS. Through these initiatives, UK will fulfill its mandate as Kentucky's flagship university to improve the health of Central Appalachia, and thereby add unique value to improvements in the health ofthe nation.
The CCTS at UK has developed well-integrated relationships with University programs in Central Appalachia and with rural health programs. We routinely apply a foundation principal of community based participatory research, where the lay community identifies ttie research issues and co-develops solutions. This proposal seeks to make research more relevant by breaking down bamers to research translation and greatly improving the pace by which science discoveries drive improvements in health in Kentucky and the nation.
|Broster, Lucas S; Li, Juan; Wagner, Benjamin et al. (2018) Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex. J Clin Exp Neuropsychol 40:761-776|
|Kerur, Nagaraj; Fukuda, Shinichi; Banerjee, Daipayan et al. (2018) cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med 24:50-61|
|Ibonia, Katrina T; Bada, Henrietta S; Westgate, Philip M et al. (2018) Blood transfusions in preterm infants: changes on perfusion index and intermittent hypoxemia. Transfusion 58:2538-2544|
|Rotroff, Daniel M; Pijut, Sonja S; Marvel, Skylar W et al. (2018) Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. Clin Pharmacol Ther 103:712-721|
|Broster, Lucas S; Jenkins, Shonna L; Holmes, Sarah D et al. (2018) Electrophysiological repetition effects in persons with mild cognitive impairment depend upon working memory demand. Neuropsychologia 117:13-25|
|Gu, Ruolei; Jiang, Yang; Kiser, Seth et al. (2017) Impulsive personality dimensions are associated with altered behavioral performance and neural responses in the monetary incentive delay task. Neuropsychologia 103:59-68|
|Brown, J Mark; Temel, Ryan E; Graf, Gregory A (2017) Para-bile-osis Establishes a Role for Nonbiliary Macrophage to Feces Reverse Cholesterol Transport. Arterioscler Thromb Vasc Biol 37:738-739|
|Abu Jawdeh, Elie G; Westgate, Philip M; Pant, Amrita et al. (2017) Prenatal Opioid Exposure and Intermittent Hypoxemia in Preterm Infants: A Retrospective Assessment. Front Pediatr 5:253|
|Godfrey, Kathryn M; Herbert, Matthew; Strachan, Eric et al. (2017) Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Clin J Pain 33:246-253|
|Li, Juan; Broster, Lucas S; Jicha, Gregory A et al. (2017) A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging. Alzheimers Res Ther 9:3|
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