Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches;a novel, 2-phase inter- disciplinary pilot award program that has already captured several NIH grants;a Website for all service request that also has a faculty directory that facilitates collaborative research;5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications;collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services;successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols;opening of the Columbia Community Partnership for Health center, one-half mile from CUMC. as a home for community-based organizations and community- based participatory research;launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding;and transformation of the """"""""old"""""""" GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers;(2) Capitalize on CUMC's outstanding T1 discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research.

Public Health Relevance

(provided by applicant): The Clinical and Translational Science Award (CTSA) allow Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
8UL1TR000040-07
Application #
8260359
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Boller, Francois
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
7
Fiscal Year
2012
Total Cost
$6,665,266
Indirect Cost
$2,267,390
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Winawer, Melodie R; Griffin, Nicole G; Samanamud, Jorge et al. (2018) Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol 83:1133-1146
Ladeiras-Lopes, Ricardo; Moreira, Henrique T; Bettencourt, Nuno et al. (2018) Metabolic Syndrome Is Associated With Impaired Diastolic Function Independently of MRI-Derived Myocardial Extracellular Volume: The MESA Study. Diabetes 67:1007-1012
Fang, Hongjuan; Berg, Elizabeth; Cheng, Xiaoguang et al. (2018) How to best assess abdominal obesity. Curr Opin Clin Nutr Metab Care 21:360-365
Madahar, Purnema; Duprez, Daniel A; Podolanczuk, Anna J et al. (2018) Collagen biomarkers and subclinical interstitial lung disease: The Multi-Ethnic Study of Atherosclerosis. Respir Med 140:108-114
Amoakwa, Kojo; Fashanu, Oluwaseun E; Tibuakuu, Martin et al. (2018) Resting heart rate and the incidence and progression of valvular calcium: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 273:45-52
Seeman, Teresa; Thomas, Duncan; Merkin, Sharon Stein et al. (2018) The Great Recession worsened blood pressure and blood glucose levels in American adults. Proc Natl Acad Sci U S A 115:3296-3301
Strand, Lauren N; Young, Rebekah L; Bertoni, Alain G et al. (2018) New statin use and left ventricular structure: Estimating long-term associations in the Multi-Ethnic Study of Atherosclerosis (MESA). Pharmacoepidemiol Drug Saf 27:570-580
Benson, Eve-Marie A; Tibuakuu, Martin; Zhao, Di et al. (2018) Associations of ideal cardiovascular health with GlycA, a novel inflammatory marker: The Multi-Ethnic Study of Atherosclerosis. Clin Cardiol 41:1439-1445
Bell, Elizabeth J; Decker, Paul A; Tsai, Michael Y et al. (2018) Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 272:162-167
Keller, Joshua P; Rice, Kenneth M (2018) Selecting Shrinkage Parameters for Effect Estimation: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:358-365

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