The UMN has witnessed unprecedented growth in biomedical research. To improve human health, our clinical and translational science institute (CTSI) will: (1) create a flexible academic infrastructure to coordinate and integrate clinical translational science (CTS) research;(2) foster transparent interactions between UMN and the community;and (3) train and reward CTS interdisciplinary UMN and community teams. Integrated functions and UMN-wide cores include the: (1) Education, Training and Research Career Development Program, supporting CTS research trainees and junior faculty with learner-tailored curricula; (2) Office of Discovery and Translation, accelerating bench-to-bedside translation and commercialization; and (3) Office of Community Engagement for Health, partnering statewide communities and UMN research. Our Biomedical Informatics Function integrates and networks clinical data and bio-specimen resources and cross-CTSI informatics infrastructure, provides training for future informatics scholars, and engages the CTS research community. Our CTSI operates on a platform accessed by an easy access entry (Front Door). Junior investigators will be vigorously supported by: (1) basic science, Tl and T2/T3 Project Development Teams;(2) rapid allocation of junior investigator-dedicated and general pilot funds;and (3) no cost access to (a) all research project managers with preferential assignment to a junior faculty specialist, (b) consultations from the service platform and (c) a junior investigator-dedicated biostatistics advisory team. All CTS mentors will be incentivized, investigators can access general pilot funds, and 3 champions will be supported. For the first time, the Community University Board will engage the UMN and community to discuss high impact health issues. By leveraging CTSA funds, strategic UMN and State investments, our community and major statewide healthcare partner support, electronic networks, special and rural community populations, MN Department of Health, the Mayo Clinic and CTSA collaborators, our CTSI will have a statewide impact on workforce training, healthcare outcomes, and policy. With award of CTSA funds, our innovative CTSI is poised to achieve our long-term goal of better health for individuals, communities, our state, and the world.

Public Health Relevance

; The UMN CTSI will improve the health of Minnesotans through CTS research by transforming the relationships among UMN, the community, and the State. Concrete partnerships will facilitate CTS discovery, translation, and knowledge dissemination. Interdisciplinary CTS research teams will be trained using new educational programs and rewarded to meet UMN and identified community needs to impact people's health.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Schools of Medicine
United States
Zip Code
Li, Danni; Huang, Fangying; Zhao, Yingchun et al. (2018) Plasma lipoproteome in Alzheimer's disease: a proof-of-concept study. Clin Proteomics 15:31
Garcia-Huidobro, Diego; Doty, Jennifer L; Davis, Laurel et al. (2018) For Whom Do Parenting Interventions to Prevent Adolescent Substance Use Work? Prev Sci 19:570-578
Cunningham, Brooke A; Scarlato, Andre S M (2018) Ensnared by Colorblindness: Discourse on Health Care Disparities. Ethn Dis 28:235-240
Keenan, Joseph C; Cortes-Puentes, Gustavo A; Zhang, Lei et al. (2018) PEEP titration: the effect of prone position and abdominal pressure in an ARDS model. Intensive Care Med Exp 6:3
Lock, Eric F; Kohli, Nidhi; Bose, Maitreyee (2018) Detecting Multiple Random Changepoints in Bayesian Piecewise Growth Mixture Models. Psychometrika 83:733-750
Nestrasil, Igor; Svatkova, Alena; Rudser, Kyle D et al. (2018) White matter measures correlate with essential tremor severity-A pilot diffusion tensor imaging study. Brain Behav 8:e01039
Burns, Michael B; Montassier, Emmanuel; Abrahante, Juan et al. (2018) Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment. PLoS Genet 14:e1007376
St Louis, James D; McCracken, Courtney E; Turk, Elizabeth M et al. (2018) Long-Term Transplant-Free Survival After Repair of Total Anomalous Pulmonary Venous Connection. Ann Thorac Surg 105:186-192
Grzywacz, Bartosz; Moench, Laura; McKenna Jr, David et al. (2018) Natural Killer Cell Homing and Persistence in the Bone Marrow After Adoptive Immunotherapy Correlates With Better Leukemia Control. J Immunother :
Desir, Snider; O'Hare, Patrick; Vogel, Rachel Isaksson et al. (2018) Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer. Sci Rep 8:9484

Showing the most recent 10 out of 1070 publications