Abstract

After a successful and highly productive first grant period, the Oregon Clinical and Translational Research Institute (OCTRI) is well positioned to have greater impact in the next grant period. OCTRI's goals are:
Specific Aim 1. Generate sustained OHSU and KPCHR research growth and productivity across the spectrum of translational science.
Specific Aim 2. Translate new biomedical knowledge into widespread advances in human health and healthcare reform.
Specific Aim 3. Create a regional consortium for clinical and translational research.
Specific Aim 4. Expand the impact of the strong OCTRI educational curriculum, develop an institution-wide, coordinated career development process that builds on the strengths of existing programs, and extend it throughout the region and nationally.
Specific Aim 5. Enhance key infrastructure programs to support local and regional clinical and translational research. These plans will build on major progress during the first grant period to further expand clinical and translational research, career development and benefits to human health. OCTRI will utilize a series of innovative partnerships to leverage CTSA support, expand its extensive collaborations with communities, and take advantage of a regional consortium of academic institutions working together to enhance translation. As a member of the CTSA Consortium, OCTRI will contribute unique expertise and resources to the combined effort to solve biomedical problems. Oregon Health and Science University and its partner institution Kaiser Permanente Center for Health Research have committed strong leadership support and substantial institutional commitment to OCTRI's continued mission.

Public Health Relevance

OCTRI will have a major influence on clinical and translational research at OHSU and KPCHR, and will increase their contributions to biomedical discovery. As the only academic medical center in Oregon, OHSU has a unique opportunity to catalyze translational research growth on a regional scale. Via its participation in the CTSA Consortium, OCTRI will advance national research productivity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR000128-08
Application #
8507816
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sufian, Meryl
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$6,630,454
Indirect Cost
$2,109,714

  Institution

Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Loy, Bryan D; Fling, Brett W; Horak, Fay B et al. (2018) Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis. Complement Ther Med 41:169-174
Schousboe, J T; Vo, T N; Langsetmo, L et al. (2018) Predictors of change of trabecular bone score (TBS) in older men: results from the Osteoporotic Fractures in Men (MrOS) Study. Osteoporos Int 29:49-59
Robinson-Cohen, Cassianne; Bartz, Traci M; Lai, Dongbing et al. (2018) Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. J Am Soc Nephrol 29:2583-2592
Gopalakrishnan, V; Spencer, C N; Nezi, L et al. (2018) Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359:97-103
Sureshchandra, Suhas; Marshall, Nicole E; Wilson, Randall M et al. (2018) Inflammatory Determinants of Pregravid Obesity in Placenta and Peripheral Blood. Front Physiol 9:1089
Wallace, Meredith L; Stone, Katie; Smagula, Stephen F et al. (2018) Which Sleep Health Characteristics Predict All-Cause Mortality in Older Men? An Application of Flexible Multivariable Approaches. Sleep 41:
Langsetmo, Lisa; Peters, Katherine W; Burghardt, Andrew J et al. (2018) Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men. J Bone Miner Res 33:1302-1311
Prola-Netto, Joao; Woods, Mark; Roberts, Victoria H J et al. (2018) Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure. Radiology 286:122-128
Holton, Kathleen F; Johnstone, Jeanette M; Brandley, Elizabeth T et al. (2018) Evaluation of dietary intake in children and college students with and without attention-deficit/hyperactivity disorder. Nutr Neurosci :1-14
Fiedler, Sarah E; Yadav, Vijayshree; Kerns, Amelia R et al. (2018) Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects. Mol Neurobiol 55:6037-6049

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