The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal:
Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff.
Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services.
Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, community- engaged research and translating comparative effectiveness research into clinical practice.
Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation.
Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies.
Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the """"""""new biology"""""""" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: """"""""To provide the best care to every patient every day through integrated clinical practice, education, and research.""""""""

Public Health Relevance

Mayo Clinic Center for Translational Science Activities will bring together all the resources of the five schools within the Mayo Clinic College of Medicine and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools, and patient care practices that impact both our local and national communities by improving their health.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR000135-09S1
Application #
8916219
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2014-09-09
Budget End
2015-03-08
Support Year
9
Fiscal Year
2014
Total Cost
$87,871
Indirect Cost
$14,767
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Dose, Ann Marie; Rhudy, Lori M (2018) Perspectives of newly diagnosed advanced cancer patients receiving dignity therapy during cancer treatment. Support Care Cancer 26:187-195
Konecny, Tomas; Somers, Kiran R; Park, Jae Yoon et al. (2018) Chronic obstructive pulmonary disease as a risk factor for ventricular arrhythmias independent of left ventricular function. Heart Rhythm 15:832-838
Collins, John D; Arch, Elisa S; Crenshaw, Jeremy R et al. (2018) Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women. Gait Posture 62:311-316
Hurtado, Maria Daniela; Cortes, Tiffany; Natt, Neena et al. (2018) Extensive clinical experience: Hypothalamic-pituitary-adrenal axis recovery after adrenalectomy for corticotropin-independent cortisol excess. Clin Endocrinol (Oxf) 89:721-733
Moriarty, James P; Shah, Nilay D; Rubenstein, Joel H et al. (2018) Costs associated with Barrett's esophagus screening in the community: an economic analysis of a prospective randomized controlled trial of sedated versus hospital unsedated versus mobile community unsedated endoscopy. Gastrointest Endosc 87:88-94.e2
Wieland, Mark L; Hanza, Marcelo M M; Weis, Jennifer A et al. (2018) Healthy Immigrant Families: Randomized Controlled Trial of a Family-Based Nutrition and Physical Activity Intervention. Am J Health Promot 32:473-484
Sohn, Sunghwan; Wi, Chung-Il; Wu, Stephen T et al. (2018) Ascertainment of asthma prognosis using natural language processing from electronic medical records. J Allergy Clin Immunol 141:2292-2294.e3
Roelfsema, Ferdinand; Yang, Rebecca J; Veldhuis, Johannes D (2018) Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men. J Endocr Soc 2:882-892
Shbeeb, Izzat; Challah, Divya; Raheel, Shafay et al. (2018) Comparable Rates of Glucocorticoid-Associated Adverse Events in Patients With Polymyalgia Rheumatica and Comorbidities in the General Population. Arthritis Care Res (Hoboken) 70:643-647
Chedid, V; Vijayvargiya, P; Carlson, P et al. (2018) Allelic variant in the glucagon-like peptide 1 receptor gene associated with greater effect of liraglutide and exenatide on gastric emptying: A pilot pharmacogenetics study. Neurogastroenterol Motil 30:e13313

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