The Yale Center for Clinical Investigation (YCCI) was created to provide a """"""""home"""""""" for training the next generation of clinical investigators. Key programmatic goals are to 1) attract highly talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering;and train them in the use of state-of-the-art research tools;give them the skills to work within complex research teams;and support their professional development;and 2) foster the translation of disease-related discoveries from the laboratory into the clinic and then the community by: stimulating the creation of interdisciplinary teams;making available state-of-the-art core facilities and expanded biostatistical and bioinformatics resources;establishing organizational and regulatory infrastructure for clinical studies;and forging new partnerships that will integrate community leaders, physicians, and health centers and encourage participation in research. Participating institutions include the Schools of Medicine, Nursing, and Public Health, the department of Biomedical Engineering and the Graduate Programs in Biological and Biomedical Sciences. The Junior Faculty Scholars award program and the Investigative Medicine program (IMP) are central to YCCI's education and training efforts. IMP is a unique doctoral program that offers Ph.D. degrees in Health Sciences Research to highly qualified M.D. fellows embarking on careers in translational or clinical research and the junior faculty scholars program is a career development program. YCCI has also created a Society of Mentors who participates actively in the training and nurturing of the YCCI Scholars. Pilot and feasibility (P&F) grants will be awarded for: 1) interdisciplinary translational team research;2) development of novel methodologies;3) Use of Core (incl imaging) technologies;and 4) community-based research. YCCI will cluster research cores around common themes, including: imaging;genomics and proteomics;cell and tissue based tech;Integrated metabolics;cognition and biobehavior;and animal models. The Office of Research Services will provide robust facilities and resources for regulatory, biostatistical, bioinformatics, recruitment and other support services. YCCI will have an office to coordinate the University's efforts to address health issues facing our community and our national community.

Public Health Relevance

This research has direct relevance to public health in that its goals are to facilitate clinical research, including by training the next generation of clinical researchers that will lead to better treatments for human disease and better health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR000142-09S1
Application #
8915805
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Merchant, Carol
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2014-09-11
Budget End
2015-03-10
Support Year
9
Fiscal Year
2014
Total Cost
$124,875
Indirect Cost
$49,875
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Sullivan, Rebecca; Abraham, Alice; Simpson, Christine et al. (2018) Three-Month Randomized Clinical Trial of Nasal Calcitonin in Adults with X-linked Hypophosphatemia. Calcif Tissue Int 102:666-670
Naganawa, Mika; Lim, Keunpoong; Nabulsi, Nabeel B et al. (2018) Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. Mol Imaging Biol 20:835-845
Perry, Rachel J; Wang, Yongliang; Cline, Gary W et al. (2018) Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell 172:234-248.e17
McNamara, Blair C; Cutler, Abigail; Lundsberg, Lisbet et al. (2018) ""I'm used to doing it by myself"": exploring self-reliance in pregnancy. BMC Pregnancy Childbirth 18:393
Snyder, Peter J; Bhasin, Shalender; Cunningham, Glenn R et al. (2018) Lessons From the Testosterone Trials. Endocr Rev 39:369-386
Benjamin, Christopher F A; Dhingra, Isha; Li, Alexa X et al. (2018) Presurgical language fMRI: Technical practices in epilepsy surgical planning. Hum Brain Mapp 39:4032-4042
Kelada, Olivia J; Decker, Roy H; Nath, Sameer K et al. (2018) High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. Int J Radiat Oncol Biol Phys 102:174-183
Wang, Yongliang; Nasiri, Ali R; Damsky, William E et al. (2018) Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Rep 24:47-55
Deshmukh, Uma; Oliveira, Carlos R; Griggs, Susan et al. (2018) Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Vaccine 36:3599-3605
Lundsberg, Lisbet S; Peglow, Stephanie; Qasba, Neena et al. (2018) Is Preconception Substance Use Associated With Unplanned or Poorly Timed Pregnancy? J Addict Med 12:321-328

Showing the most recent 10 out of 790 publications