The CTSA funding to the Michigan Institute for Clinical and Health Research (MICHR) in 2007 marked the beginning of a transformation of clinical-translational research (CTR) at the University of Michigan (UM). This award, coupled with strong institutional support and growing faculty engagement, enabled UM to evolve from a predominantly basic science research institution to one with a comprehensive research portfolio. This has been achieved on the foundation of: integrated and innovative training and educational programs that have touched nearly 2,000 trainees, faculty and staff; centralization and optimization of previously fragmented research services to create innovative opportunities for users; $10.2M distributed for pilot studies to accelerate innovation; and researcher participation in new partnerships with our communities and across the CTSA National Consortium. In the renewal period, CTSA funding leveraged with robust institutional support will enable MICHR to pursue 5 Overarching Objectives: 1) Optimize training and mentoring to create the next generation of research teams and clinical and translational investigators; 2) Augment infrastructure and refine research services to reduce barriers and maximize research productivity across the entire translational research continuum; 3) Foster collaborations and leverage innovative approaches and technologies to catalyze discovery; 4) Enhance community- and practice-based partnerships to assure bi-directional learning, research, and implementation of findings to benefit health; 5) Actively lead and contribute to national CTSA Consortium activities and engage in cross-CTSA collaborations. These will be achieved by: expanding education into new areas to strengthen the pipeline of CTR investigators and deploying more flexible training tools; strengthening existing services and launching new ones to impact study start-up times and recruitment; employing major informatics investments to fully integrate the needs of CTR investigators into IT landscape; utilizing new practice-based research networks; expanding evaluation to efficiently assess and optimize our performance. MICHR will be the engine of improvement and innovation in the conduct of high-quality, high impact-clinical and translational research to advance the health of Michigan and the nation.

Public Health Relevance

Translating scientific discoveries into real health gains is challenging. In recent decades this translation has been taking longer and costing more. The Michigan Institute for Clinical and Health Research provides infrastructure and services for researchers and increases access to research for the community. We help transform emerging knowledge into real changes in how we prevent and treat disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
4UL1TR000433-10
Application #
9070791
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Wilson, Todd
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Schofield, Heather K; Zeller, Jörg; Espinoza, Carlos et al. (2018) Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight 3:
Murphy, Susan L; Janevic, Mary R; Lee, Pearl et al. (2018) Occupational Therapist-Delivered Cognitive-Behavioral Therapy for Knee Osteoarthritis: A Randomized Pilot Study. Am J Occup Ther 72:7205205040p1-7205205040p9
Zimmerman, Lauren L; Gupta, Priyanka; O'Gara, Florence et al. (2018) Transcutaneous Electrical Nerve Stimulation to Improve Female Sexual Dysfunction Symptoms: A Pilot Study. Neuromodulation 21:707-713
Seekatz, Anna M; Wolfrum, Emily; DeWald, Christopher M et al. (2018) Presence of multiple Clostridium difficile strains at primary infection is associated with development of recurrent disease. Anaerobe :
Julian, Megan M; Rosenblum, Katherine L; Doom, Jenalee R et al. (2018) Oxytocin and parenting behavior among impoverished mothers with low vs. high early life stress. Arch Womens Ment Health 21:375-382
Carlozzi, Noelle E; Ianni, Phillip A; Tulsky, David S et al. (2018) Understanding Health-Related Quality of Life in Caregivers of Civilians and Service Members/Veterans With Traumatic Brain Injury: Establishing the Reliability and Validity of PROMIS Fatigue and Sleep Disturbance Item Banks. Arch Phys Med Rehabil :
Na, Peter J; Yaramala, Satyanarayana R; Kim, Jihoon A et al. (2018) The PHQ-9 Item 9 based screening for suicide risk: a validation study of the Patient Health Questionnaire (PHQ)-9 Item 9 with the Columbia Suicide Severity Rating Scale (C-SSRS). J Affect Disord 232:34-40
Rahman, Mahboob; Hsu, Jesse Yenchih; Desai, Niraj et al. (2018) Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease. Clin J Am Soc Nephrol 13:585-595
Jo, Janggun; Tian, Chao; Xu, Guan et al. (2018) Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection. Photoacoustics 12:82-89
Carlozzi, Noelle E; Kallen, Michael A; Ianni, Phillip A et al. (2018) The Development of a New Computer-Adaptive Test to Evaluate Strain in Caregivers of Individuals With TBI: TBI-CareQOL Caregiver Strain. Arch Phys Med Rehabil :

Showing the most recent 10 out of 776 publications