This application, in response to RFA TR-12-006: """"""""Institutional Clinical and Translational Science Award (U54)"""""""", requests support for the University of Utah's Center for Clinical and Translational Science (CCTS). Our CCTS is built upon the UU's historic strengths in genetics and bioinformatics. Our vision for the next five years is to maintain and leverage the service cores of the CCTS and use that infrastructure as a springboard to launch new programs. With implementation of this vision we will fulfill the Aims of the CTSA described in the FOA by maintaining a home for translational research to: (1) Increase the quality, quantity, safety, efficiency, and impact of translational research for all conditions;(2) Provide resources and services to support and speed the planning and implementation of clinical and translational research across the entire range of research and communities;(3) Train, mentor, and support the next generation of translational investigators through the stage of becoming principal investigators and productive faculty members;(4) Maintain a governance structure that represents the full spectrum of translational science and all of its stakeholders to effectively fulfill the Aims;(5) Engage in a process of continuous evaluation, improvement, and innovation in all of these areas. The mission of the UU CCTS will be to provide support for all aspects of translational research. Even support that can be characterized as """"""""service"""""""" will be used to inform innovation and catalyze new thinking. In addition, we will direct new resources toward providing special expertise to the CTSA consortium in specific areas, namely: Human genetics;genotype/phenotype correlation;health services research including comparative effectiveness;medical device innovation, and;taking the electronic medical record to the next level as a tool for medical care and medical research. We will continue to perform research aimed at re-engineering the process of translational investigation.

Public Health Relevance

; Providing resources and services to support and speed the planning and implementation of clinical and translational research across the entire range of research and communities.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Brazhnik, Olga
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University of Utah
Internal Medicine/Medicine
Schools of Medicine
Salt Lake City
United States
Zip Code
Johnson, Joshua K; Lohse, Bryan; Bento, Haley A et al. (2018) Improving Outcomes for Critically Ill Cardiovascular Patients Through Increased Physical Therapy Staffing. Arch Phys Med Rehabil :
Chalmers, Peter N; Ross, Hunter; Granger, Erin et al. (2018) The Effect of Rotator Cuff Repair on Natural History: A Systematic Review of Intermediate to Long-Term Outcomes. JB JS Open Access 3:e0043
Peterson, K A; Yoshigi, M; Hazel, M W et al. (2018) RNA sequencing confirms similarities between PPI-responsive oesophageal eosinophilia and eosinophilic oesophagitis. Aliment Pharmacol Ther 48:219-225
Fritz, Julie M; Sharpe, Jason A; Lane, Elizabeth et al. (2018) Optimizing treatment protocols for spinal manipulative therapy: study protocol for a randomized trial. Trials 19:306
Martin, Christopher; Leiser, Claire L; O'Neil, Brock et al. (2018) Familial Cancer Clustering in Urothelial Cancer: A Population-Based Case-Control Study. J Natl Cancer Inst 110:527-533
Tonna, Joseph E; Kawamoto, Kensaku; Presson, Angela P et al. (2018) Single intervention for a reduction in portable chest radiography (pCXR) in cardiovascular and surgical/trauma ICUs and associated outcomes. J Crit Care 44:18-23
Ho, Karen S; Markham, Leah M; Twede, Hope et al. (2018) A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome. Epilepsy Behav 81:55-61
Schlaberg, Robert; Barrett, Amanda; Edes, Kornelia et al. (2018) Fecal Host Transcriptomics for Non-Invasive Human Mucosal Immune Profiling: Proof of Concept in Clostridium Difficile Infection. Pathog Immun 3:164-180
Ostrander, Betsy E P; Butterfield, Russell J; Pedersen, Brent S et al. (2018) Whole-genome analysis for effective clinical diagnosis and gene discovery in early infantile epileptic encephalopathy. NPJ Genom Med 3:22
Theilen, Lauren H; Meeks, Huong; Fraser, Alison et al. (2018) Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy. Am J Obstet Gynecol 219:107.e1-107.e6

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