The Johns Hopkins Institute for Clinical and Translational Research (ICTR) is dedicated to creating a new model for conducting clinical and translational research throughout the Johns Hopkins University, by addressing critical obstacles that impede the progress of basic science discoveries to the clinic, clinical discoveries into the community and results back to the research community. To propel additional high impact and efficient translational research, the ICTR will create Translational Research Communities and The Studio. Three Translational Research Communities will be organized around: 1) drugs, biologies, vaccines and devices; 2) biomarkers and diagnostic tests and 3) behavioral, social and systems interventions. These communities of researchers will help prioritize important clinical problems, develop new technologies and methodologies, support junior investigators, work with translational partners outside of Johns Hopkins, and promote efficient research. The Studio is both a place and a process by which research teams can present problems and get integrated, efficient, multidisciplinary consultations from multiple experts. With the emergence of complex big data originating from genomic as well as electronic health records, the ICTR has expanded the Quantitative Methodologies and Informatics Cores to create an integrated platform of data services. These new programs will assist our multiple research teams across the University to access a large array of services provided in five ICTR Cores: Translational Science, Human Subjects Research, Quantitative Methodology, Informatics and Research Participant and Community Partnership. Translational research is changing with more ambitious goals and access to more tools. Johns Hopkins University will continue to provide rigorous, comprehensive training to learners that range from graduate students, fellows, and junior faculty to practicing physicians so they are able to lead and work effectively in translational research teams. Through these innovative and comprehensive programs, the ICTR wants to lead Johns Hopkins University to be an exceptional engine of discovery and innovation.

Public Health Relevance

By identifying and overcoming barriers in the translational pathway, increasing scientific collaboration, providing consultative services, clinical infrastructure, and technology cores that bridge the gap between the laboratory and the clinic, the ICTR helps to speed the pace of scientific discovery, and bring effective therapies to the public, and improve the health of Americans.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001079-03
Application #
8889744
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Brazhnik, Olga
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
3
Fiscal Year
2015
Total Cost
$12,911,237
Indirect Cost
$2,278,633
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
McCaul, Mary E; Wand, Gary S; Weerts, Elise M et al. (2018) A paradigm for examining stress effects on alcohol-motivated behaviors in participants with alcohol use disorder. Addict Biol 23:836-845
Robinson-Cohen, Cassianne; Bartz, Traci M; Lai, Dongbing et al. (2018) Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. J Am Soc Nephrol 29:2583-2592
Besser, Lilah M; Rodriguez, Daniel A; McDonald, Noreen et al. (2018) Neighborhood built environment and cognition in non-demented older adults: The Multi-Ethnic Study of Atherosclerosis. Soc Sci Med 200:27-35
Bharathy, Narendra; Berlow, Noah E; Wang, Eric et al. (2018) The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma. Sci Signal 11:
Wu, Minjie; Fatukasi, Omalara; Yang, Shaolin et al. (2018) HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition. AIDS 32:1803-1810
Everett, Estelle; Kane, Brian; Yoo, Ashley et al. (2018) A Novel Approach for Fully Automated, Personalized Health Coaching for Adults with Prediabetes: Pilot Clinical Trial. J Med Internet Res 20:e72
Lyu, Junfang; Yang, Eun Ju; Head, Sarah A et al. (2018) Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. Int J Biol Sci 14:1175-1185
Gao, Chuan; Langefeld, Carl D; Ziegler, Julie T et al. (2018) Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans. Obesity (Silver Spring) 26:202-212
Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :
Dunn, Erin C; Sofer, Tamar; Wang, Min-Jung et al. (2018) Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos. J Psychiatr Res 99:167-176

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