The overarching goal of this proposal is to support and enhance our institutionally-funded Dartmouth Center for Clinical and Translational Science, called SYNERGY-an integrated home for clinical and translational science at Dartmouth. Dartmouth launched SYNERGY in 2010, a Center built on Dartmouth's richly collaborative and collegial culture, its interdisciplinary life sciences and health services research programs, and its commitment to accelerating the translation of scientific knowledge into practice and improved population health. Over the past two years, fueled by Dartmouth's resources, and by the """"""""Center status"""""""" and authority given by Dartmouth's leaders, SYNERGY has taken bold steps to begin to transform the institution's landscape for clinical and translational research. We propose four overarching aims designed to continue to expand our ability to conduct decisive science on the biology of disease and to use new and existing knowledge to transform the practice of medicine and thus to improve health-locally, regionally and nationally. Over the next five years we will: (1) strengthen SYNERGY to achieve greater interdisciplinary and programmatic research synergism and efficiency and promote an institutional culture aimed at advancing clinical and translational science;(2) ensure that SYNERGY investigators can easily and efficiently access resources and services, and thus enhance their productivity;(3) expand and integrate training and career development programs to build research focus and passion among trainees from diverse disciplines who aim to build successful careers in clinical and translational research;and (4) create a Center for Translational Population Research , a technical and analytic resource that harnesses the value of population-based research across the spectrum from T l (basic research) to T4 (population research and health policy), as a resource both for Dartmouth and for the national CTSA consortium. Dartmouth is united to ensure that SYNERGY will continue to transform the landscape for clinical and translational research locally, regionally, and-as a member of the CTSA consortium-nationally, and thus to improve population health.

Public Health Relevance

Dartmouth has a history of collaborative research and interdisciplinary education in the life sciences and health services research that have led to the creation of Dartmouth's Center for Clinical and Translational Science, named SYNERGY. As proposed in this application, SYNERGY will be expanded to support the efficient and rapid translation of scientific findings into clinical care and improved population health.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR001086-01
Application #
8721021
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Purucker, Mary E
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2013-09-26
Budget End
2014-04-30
Support Year
1
Fiscal Year
2013
Total Cost
$2,050,174
Indirect Cost
Name
Dartmouth College
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Bekelis, Kimon; Missios, Symeon; MacKenzie, Todd A (2018) Correlation of hospital magnet status with the quality of physicians performing neurosurgical procedures in New York State. Br J Neurosurg 32:13-17
Green, Alan I; Khokhar, Jibran Y (2018) Addiction and schizophrenia: A translational perspective. Schizophr Res 194:1-3
Khokhar, Jibran Y; Dwiel, Lucas L; Henricks, Angela M et al. (2018) The link between schizophrenia and substance use disorder: A unifying hypothesis. Schizophr Res 194:78-85
Dhingra, Sourabh; Buckey, Jay C; Cramer, Robert A (2018) Hyperbaric Oxygen Reduces Aspergillus fumigatus Proliferation In Vitro and Influences In Vivo Disease Outcomes. Antimicrob Agents Chemother 62:
Nasir, Mavra; Bean, Heather D; Smolinska, Agnieszka et al. (2018) Volatile molecules from bronchoalveolar lavage fluid can 'rule-in' Pseudomonas aeruginosa and 'rule-out' Staphylococcus aureus infections in cystic fibrosis patients. Sci Rep 8:826
Andrew, Angeline S; Chen, Celia Y; Caller, Tracie A et al. (2018) Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk. Muscle Nerve :
Barr, Fiona D; Ochsenbauer, Christina; Wira, Charles R et al. (2018) Neutrophil extracellular traps prevent HIV infection in the female genital tract. Mucosal Immunol 11:1420-1428
Crow, Rebecca S; Lohman, Matthew C; Pidgeon, Dawna et al. (2018) Frailty Versus Stopping Elderly Accidents, Deaths and Injuries Initiative Fall Risk Score: Ability to Predict Future Falls. J Am Geriatr Soc 66:577-583
Han, David S; Zhou, Weiping; Seigne, John D et al. (2018) Geographic Variation in Cystoscopy Rates for Suspected Bladder Cancer between Female and Male Medicare Beneficiaries. Urology 122:83-88
Bekelis, Kimon; Missios, Symeon; Shu, Joel et al. (2018) Surgical outcomes for patients diagnosed with dementia: A coarsened exact matching study. J Clin Neurosci 53:160-164

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