Contact PD/PI: Brady, Kathleen Theresa OVERALL: PROJECT SUMMARY As part of the CTSA consortium since 2009, the South Carolina Translational and Clinical Research Institute (SCTR) created an academic home for clinical and translational research in South Carolina that has transformed the research environment across the state with the goal of accelerating efficient translation of biomedical discoveries into improvements in human health. Headquartered at the Medical University of South Carolina (MUSC) in Charleston, SCTR created a ?front door? for access to statewide research resources, providing more than 700 direct consultations and innumerable website ?hits? each year. We successfully engaged local and regional stakeholder communities in facilitating and guiding research, implementation and dissemination activities. We catalyzed the formation of interdisciplinary research teams through innovative translational pilot projects and integrated training programs. We worked across the state and with national CTSA colleagues to streamline and improve efficiencies in research processes, including the development of a research service ordering and fulfillment system (SPARC) that is deployed within SCTR and four other CTSA hubs. A major focus of this renewal application is to advance Learning Health System (LHS) principles by: (a) providing real-time access to data to guide decision-making and continuous quality improvement efforts, (b) facilitating robust relationships with patients and other stakeholders to ensure clinical and translational research relevance, and (c) fostering a culture of collaboration, teamwork and adaptability. We will work with SCTR affiliates in South Carolina and collaborate with the CTSA Network to achieve the following specific aims: 1) Build on our clinical and translational research strengths to enrich and expand our integrated, statewide research environment and expand our CTSA Network collaborations; 2) Develop and implement high quality, innovative, flexible curricula and training experiences for all levels of the translational research workforce with a focus on enhancing diversity and advancing team science; 3) Promote community engagement throughout the translational research continuum and facilitate robust relationships with patients and other stakeholders to ensure CTR relevance; 4) Create an efficient enterprise-wide clinical and translational research ?Quality System? driven by continuous quality improvement and innovation; and 5) Promote the engagement of diverse populations across the lifespan in clinical and translational research. Project Summary/Abstract Page 279 Contact PD/PI: Brady, Kathleen Theresa

Public Health Relevance

The South Carolina Clinical & Translational Research Institute (SCTR) has established strong training and infrastructure resources with the goal of accelerating efficient translation of biomedical research into improvements in human health. A major focus of this application is to continue to foster a culture of collaboration, teamwork and adaptability among scientists, health professionals and community members across South Carolina and beyond as part of a national network to ensure that scientific discovery is relevant and rapidly translated to front-line treatment settings for maximum impact on health outcomes. Project Narrative Page 280

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Purucker, Mary E
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Medical University of South Carolina
Schools of Medicine
United States
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Scott, Lancer A; Madden, Layne A; Wahlquist, Amy E et al. (2018) Preparing for the Surge: A Half-Day Emergency Preparedness Training Course for the ""Second Front"". Disaster Med Public Health Prep 12:121-126
Luque, John S; Tarasenko, Yelena N; Li, Hong et al. (2018) Utilization of Cervical Cancer Screening Among Hispanic Immigrant Women in Coastal South Carolina. J Racial Ethn Health Disparities 5:588-597
Fabie, Joshua E; Hatch, Jonathan L; Cross, Ashley W et al. (2018) Metastatic Salivary Ductal Carcinoma to the Mastoid Segment of the Facial Nerve. Otol Neurotol 39:e722-e725
Shih, Andy Y; Hyacinth, Hyacinth I; Hartmann, David A et al. (2018) Rodent Models of Cerebral Microinfarct and Microhemorrhage. Stroke 49:803-810
Alawieh, Ali; Zhao, Jing; Feng, Wuwei (2018) Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury. Behav Brain Res 340:94-101
Schlenz, Alyssa M; Hayes, Joannie; Mueller, Martina et al. (2018) Incomplete implementation of guideline-based stroke prevention therapy in sickle cell disease. Am J Hematol 93:E222-E224
McRackan, Theodore R; Clinkscales, William B; Ahlstrom, Jayne B et al. (2018) Factors associated with benefit of active middle ear implants compared to conventional hearing aids. Laryngoscope 128:2133-2138
McClure, Erin A; Tomko, Rachel L; Carpenter, Matthew J et al. (2018) Acceptability and compliance with a remote monitoring system to track smoking and abstinence among young smokers. Am J Drug Alcohol Abuse 44:561-570
Evans, Spencer C; Boan, Andrea D; Bradley, Catherine et al. (2018) Sex/Gender Differences in Screening for Autism Spectrum Disorder: Implications for Evidence-Based Assessment. J Clin Child Adolesc Psychol :1-15
Rycenga, Halley B; Long, David T (2018) The evolving role of DNA inter-strand crosslinks in chemotherapy. Curr Opin Pharmacol 41:20-26

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