Contact PD/PI: GINSBERG, HENRY N OVERALL ABSTRACT Our CTSA Hub is situated in the Irving Institute for Clinical and Translational Research (Irving Institute) of Columbia University (CU), and based at the CU Medical Center (CUMC) in Northern Manhattan (NM). The CU College of Physicians and Surgeons (P&S), Mailman School of Public Health (MSPH), College of Dental Medicine (CDM), and School of Nursing (SON) are all at CUMC together with major components of New York Presbyterian Hospital (NYP) and the New York State Psychiatric Institute (NYSPI). The vision of the Irving Institute is: 1) to transform the culture of biomedical research enabling CUMC investigators to develop new treatments faster and deliver those treatments to patients more efficiently, effectively, and safely than ever before; 2) to utilize medical research advances to benefit patients and the community, converting knowledge into practice; and 3) to recruit, train, support and nurture the next generation of clinical and translational investigators in multi- and interdisciplinary team science environments. Since first receiving CTSA funding in 2006, we embraced a vision that would impact maximally on a) individuals, particularly junior faculty and trainees, b) groups of faculty and trainees working in common areas of interest but often in relative isolation, and 3) the institutional culture. We believed that this bottom-up approach was necessary if we were to move CUMC from a system that rewarded individual effort more than the achievements of groups. After nine years, we are certain that we have changed the environment significantly, and that CUMC and NYP both understand that multidisciplinary team efforts are essential for success in this era of greater complexity both in science and in clinical care. Additionally, we all have come to understand that only by engaging our patients early in the research process, particularly those individuals in the communities of Northern Manhattan (NM), will we gain their trust and enthusiasm, two keys to their participation in the revolution generated by Precision Medicine.
Our aim i s to expand, enhance, and improve the Irving Institute's CTSA Hub, to ensure that we create an outstanding environment where junior and senior faculty, trainees, clinical research coordinators, nurses, support staff, and patients, particularly members of the underserved and underrepresent communities of NM are all engaged in, and benefit from, our efforts to meet the exciting and unique opportunities afforded by the CU/NYP Precision Medicine Initiative and the extraordinary advancements in information technologies, `omics', and therapeutic possibilities. Innovations and achievements at our Hub will be disseminated for the benefit of our local neighboring Hubs and the CTSA Hub Network. Project Summary/Abstract Page 162 Contact PD/PI: GINSBERG, HENRY N Narrative The Clinical and Translational Science Award (CTSA) allows Columbia University to support novel programs whose goal is to speed the transition from scientific discoveries made in the laboratory toward new therapies. We will conduct and support research, training, health information dissemination, and other programs with respect to translational science. We will facilitate the training of scholars from diverse backgrounds underrepresented in translational science who are knowledgeable about and available to focus on translational science later in their careers.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Talbot, Bernard
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Budget End
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Fiscal Year
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Indirect Cost
Columbia University (N.Y.)
Internal Medicine/Medicine
Schools of Medicine
New York
United States
Zip Code
Postigo-Fernandez, Jorge; Creusot, Rémi J (2018) A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes. J Autoimmun :
Mirelman, Anat; Saunders-Pullman, Rachel; Alcalay, Roy N et al. (2018) Application of the Movement Disorder Society prodromal criteria in healthy G2019S-LRRK2 carriers. Mov Disord 33:966-973
Kronish, Ian M; Edmondson, Donald; Moise, Nathalie et al. (2018) Posttraumatic stress disorder in patients who rule out versus rule in for acute coronary syndrome. Gen Hosp Psychiatry 53:101-107
Anderson, Brett R; Fieldston, Evan S; Newburger, Jane W et al. (2018) Disparities in Outcomes and Resource Use After Hospitalization for Cardiac Surgery by Neighborhood Income. Pediatrics 141:
Ndumele, Chiadi E; Cobb, Laura; Lazo, Mariana et al. (2018) Weight History and Subclinical Myocardial Damage. Clin Chem 64:201-209
Abaci, Hasan Erbil; Coffman, Abigail; Doucet, Yanne et al. (2018) Tissue engineering of human hair follicles using a biomimetic developmental approach. Nat Commun 9:5301
Butler, Alex; Wei, Wei; Yuan, Chi et al. (2018) The Data Gap in the EHR for Clinical Research Eligibility Screening. AMIA Jt Summits Transl Sci Proc 2017:320-329
Zahodne, Laura B; Schupf, Nicole; Brickman, Adam M (2018) Control beliefs are associated with preserved memory function in the face of low hippocampal volume among diverse older adults. Brain Imaging Behav 12:1112-1120
Shechter, Ari; Kim, Elijah Wookhyun; St-Onge, Marie-Pierre et al. (2018) Blocking nocturnal blue light for insomnia: A randomized controlled trial. J Psychiatr Res 96:196-202
Laferrère, Blandine; Pattou, François (2018) Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass. Front Endocrinol (Lausanne) 9:530

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