TheUniversityofKentucky(UK)CenterforClinicalandTranslationalScience(CCTS)hascreatedan integratedhomeforclinicalandtranslationalresearchtopromotescientificprogressanddiscoveriesatevery phaseofthetranslationalcontinuum.TheCCTShasfundamentallytransformedtheresearchenvironmentnot onlyatUKbutthroughoutCentralAppalachiathroughthedevelopmentofastrongresearchnetwork,the AppalachianTranslationalResearchNetwork(ATRN),withintegratedresearchpartnershipsincludingother CTSAhubs.Whencombinedwithanin-depthunderstandingoftheuniqueandserioushealthchallenges facedbyCentralAppalachianresidents,theUKCCTSispositionedtoleadlocal,regionalandnational researcheffortsthatfocusonthesignificanthealthdisparitiesinthispopulation.Ouroverarchinggoalasa CTSAhubistocontinuetochampioninnovationinthefullspectrumofclinicalandtranslationalresearchwhile educatingtheworkforceofthefuture,engagingourcommunitiesinbiomedicalscienceandworkingwiththe nationalnetworktoadvancecohesivemulti-centerclinicaltrials,whichwillultimatelyelevatethehealthand qualityoflifeofthepopulaceofCentralAppalachia.Specifically,theUKCCTSwill:1)Leadinstitutional innovationinthedeliveryofefficient,effectiveclinicalandtranslationalresearch.2)Developadiverse workforceacrossmultipledisciplinesthatadvancestranslationalresearchandexcelsinteam-basedscience. 3)MeettheuniqueneedsofCentralAppalachianresidentsbyextensivelyengagingandcollaboratingwithour regional,ruralandcommunity-basedpartners.4)Catalyzeinnovativeresearch,includingnoveldrug developmentandinformaticsmethodologies,withparticularfocusonbringinginnovationtospecialpopulations andacrossthelifespan.5)Createanefficientclinicaltrialsnetwork,centeredatUK,andextendingintoour partnerhealthcaresystemsthatwillbeanessentialandleadingcomponentoftheCTSAconsortium,involving participantsthroughoutafourstateregionofruralCentralAppalachia.TheUKCCTSbenefitsfroma collaborativeenvironmentfoundononlyafewuniversitycampuses.UKhas16colleges,with11involvedin theUKCCTS(includingsixbiomedicalcolleges)ononecentralcampus.Thisphysicalproximityofour academicandhealthcarecommunities,alongwithacultureofcollaboration,createsacloselyknitunified academiccommunityandpositionstheUKCCTStodemonstratetheimpactofcollaborativetranslational researchandleadershipinteamscience.Oureffortshavealreadybeensuccessfulattransformingtheculture oftheUKacademicmedicalcentertoonethatmorekeenlyappreciatesscholarship,innovationand translationalscience.Wenowplantobuildonthesestrengthstoadvancetranslationalsciencetothenext level,withfurtherdevelopmentofourclinicaltrialnetworks,developmentofnovelinformaticsprograms,and continueddevelopmentoftheworkforcethroughouttheregion.Theseeffortswillbenefitthemedically underservedresidentsofCentralAppalachiaandwillsignificantlycontributetothenationalCTSAprogram. 1 Project Summary/Abstract Page 287 Contact PD/PI: Kern, Philip A
The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) is strategically positioned in Central Appalachia to catalyze efforts to connect the populace of this medically underserved region, with significant health disparities, to the national CTSA network. The UK CCTS is recognized locally and regionally for affecting change and building robust partnerships across the CTSA network, in Central Appalachia and at UK, creating an efficient platform for clinical and translational research and training, all to improve quality of care, health, and well-being for the rural populations of this region. 1 Project Narrative Page 288
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