Contact PD/PI: Kieburtz, Karl O: OVERALL CORE ? PROJECT SUMMARY/ABSTRACT The University of Rochester Clinical and Translational Science Institute (UR-CTSI) is located in Upstate New York, and affiliated with the University of Rochester and the University of Rochester Medical Center (URMC), which provides advanced healthcare for Upstate and Western New York and is the premier translational research institution in the region. The mission of the UR-CTSI is to develop, demonstrate and disseminate methods and approaches to advance translational research, by: 1) providing education and training, 2) fostering transdisciplinary teams, 3) improving quality and efficiency, and 4) engaging com-munity and national stakeholders and partners. Our vision is to become a replicable model environment for re-search, across the translational spectrum from molecules to populations, responsive to community priorities, conducted by transdisciplinary, patient- and community-engaged teams, that improves population health. We build on a decade of exceptional accomplishments in translational research: vibrant workforce training programs, national contributions to translational research methods and education, and exceptional productivity of UR-CTSI supported translational researchers. We train leaders in clinical and translational team science, including data science, informatics, regulatory science, and population science. We are committed to diversity in workforce training, community engagement, and research participant recruitment. The UR-CTSI fosters transdisciplinary teams, connecting them with resources, and tracking metrics of success to continuously improve research quality and efficiency. We direct pilot programs that accelerate translation of basic science and bedside discoveries into clinical therapeutics, and develop novel research competency and regulatory science programs. We advance translational research by developing innovative informatics methods and innovative research support. A cornerstone of our work is the dynamic integration of healthcare delivery and translational research, clinical trials, and implementation of novel evidence-based interventions, which together form the ?living healthcare laboratory,? at URMC. Project Summary/Abstract Page 358 Contact PD/PI: Kieburtz, Karl O. OVERALL CORE ?

Public Health Relevance

The University of Rochester Clinical and Translational Science Institute develops, demonstrates and disseminates methods and approaches to advance translational research, by providing education and training, fostering transdisciplinary teams, improving quality and efficiency, and engaging community and national stakeholders and partners. The ultimate result will be to increase the impact of transdisciplinary research programs, projects and teams focused on translational research: from basic science discovery to population health improvement, and from challenges in population health to innovations in basic science. Project Narrative Page 359

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR002001-03S1
Application #
9694430
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Hsiao, H Timothy
Project Start
2016-08-15
Project End
2020-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
School of Medicine & Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Rashid, Kahkashan; Sundar, Isaac K; Gerloff, Janice et al. (2018) Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. Sci Rep 8:9023
Wong, Elissa L; Lutz, Nina M; Hogan, Victoria A et al. (2018) Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun 67:257-278
Nogales, Aitor; Piepenbrink, Michael S; Wang, Jiong et al. (2018) A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody. Sci Rep 8:4374
Wang, Yuchen; Newman, Maureen R; Benoit, Danielle S W (2018) Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review. Eur J Pharm Biopharm 127:223-236
Sundar, Isaac K; Rashid, Kahkashan; Gerloff, Janice et al. (2018) Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. FASEB J 32:4955-4971
Ayoub, Edward; Wilson, Michael P; McGrath, Kathleen E et al. (2018) EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription. Nat Commun 9:4239
Zhang, Xue-Lian; Yuan, Ming-Xia; Wan, Gang et al. (2018) The effects of AER and eGFR on outcomes of CVD in patients with T2DM in an urban community over 8 years of multifactorial treatment: the Beijing Communities Diabetes Study 18. Ther Clin Risk Manag 14:1537-1545
Wittink, Marsha N; Walsh, Patrick; Yilmaz, Sule et al. (2018) Patient priorities and the doorknob phenomenon in primary care: Can technology improve disclosure of patient stressors? Patient Educ Couns 101:214-220
Rosenberg, Avi Z; Wright, Carrie; Fox-Talbot, Karen et al. (2018) xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells. Sci Rep 8:9783
Halushka, Marc K; Fromm, Bastian; Peterson, Kevin J et al. (2018) Big Strides in Cellular MicroRNA Expression. Trends Genet 34:165-167

Showing the most recent 10 out of 32 publications