Contact PD/PI: MERMELSTEIN, ROBIN J ABSTRACT The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) seeks to catalyze translational research, locally and nationally, as part of a national network to improve individual and population health. The UIC CCTS, first funded by NIH in 2009, has had a transformative effect on accelerating clinical translational research by influencing the culture, processes, and practices at UIC and increasing the pipeline and training for clinical translational scientists. The UIC CCTS continues to have the necessary capacities and resources to be a full and well-qualified partner in this national CTSA program. We are committed to the current focus of the CTSA program, including workforce development; collaborating with a broad range of stakeholders to advance translation; integrating across the translational spectrum, lifespan, and diverse populations; improving and innovating the methods and processes for efficient collaborative clinical translational research; and supporting and advancing the use of informatics solutions to advance clinical translational research. We are well positioned to make substantial contributions by collaborating with other hubs, supporting national CTSA activities, and making unique contributions to community-engaged research with vulnerable and underserved populations.
The specific aims of our CCTS are to: 1) Develop a skillful and diverse translational workforce to conduct multidisciplinary team science and advance translation of discoveries; 2) Engage a broad range of stakeholders in clinical translational research, including patients, community leaders, health care providers and clinicians, industry and policy makers. We will support collaboration among the CTSA hubs, participate in multi-site trials, provide multi-site study support, and provide enhanced capacity for recruitment and retention; 3) Integrate, support, and accelerate clinical translational research across the full translational spectrum with multiple disciplines and with diverse populations across the lifespan; 4) Promote advances in study and development of methods and processes of conducting translational science that will enable advances in translation; and 5) Support the use and advance of innovative informatics solutions to advance translational research and to help train the CTSA workforce. We will accomplish these aims with a coherent and streamlined structure and with an effective leadership and administration that will ensure ongoing evaluation, monitoring, and continued process improvements.
These aims will direct our course over the next five years, as we further evolve the clinical and translational enterprise, contribute to the CTSA network, and advance the health of the people of Illinois and the nation. Project Summary/Abstract Page 99 Contact PD/PI: MERMELSTEIN, ROBIN J NARRATIVE The University of Illinois at Chicago Center for Clinical and Translational Science (UIC CCTS) proposes to be a robust and highly contributory hub in the national CTSA program that both advances and applies clinical translational research in a timely manner and expands and diversifies the clinical translational workforce. The overarching goal - and driving focus - of UIC CCTS is to improve population health, particularly among minorities and underserved populations across the lifespan. Today's health problems are complex, and addressing them requires the integrated collaborative efforts of scientists and practitioners along the translational spectrum, along with processes to overcome translational barriers. We propose a suite of programs and processes that will help accelerate the translation of scientific discoveries into practice and to overcome the challenges of addressing the complex health problems of today.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Wilde, David B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
Other Domestic Higher Education
United States
Zip Code
Metwally, Ahmed A; Yang, Jie; Ascoli, Christian et al. (2018) MetaLonDA: a flexible R package for identifying time intervals of differentially abundant features in metagenomic longitudinal studies. Microbiome 6:32
Han, Jin; Zhou, Jifang; Saraf, Santosh L et al. (2018) Characterization of opioid use in sickle cell disease. Pharmacoepidemiol Drug Saf 27:479-486
Matthews, Alicia K; Breen, Elizabeth; Kittiteerasack, Priyoth (2018) Social Determinants of LGBT Cancer Health Inequities. Semin Oncol Nurs 34:12-20
Rydzon, Brett; Monson, Rebecca S; Oberholzer, Jose et al. (2018) Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes. Diabetes Metab Res Rev 34:
Liu, Eden; Hsueh, Leon; Kim, Hajwa et al. (2018) Global geographical variation in patient characteristics in percutaneous coronary intervention clinical trials: A systematic review and meta-analysis. Am Heart J 195:39-49
Chukwudozie, Ifeanyi Beverly; Fitzgibbon, Marian L; Schiffer, Linda et al. (2018) Facilitating primary care provider use in a patient-centered medical home intervention study for chronic hemodialysis patients. Transl Behav Med 8:341-350
Bunnell, Kristen L; Pai, Manjunath P; Sikka, Monica et al. (2018) Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II, and III) Adult Subjects. Antimicrob Agents Chemother 62:
Muramatsu, Naoko; Yin, Lijuan; Berbaum, Michael L et al. (2018) Promoting Seniors' Health With Home Care Aides: A Pilot. Gerontologist 58:779-788
Shankman, Stewart A; Funkhouser, Carter J; Klein, Daniel N et al. (2018) Reliability and validity of severity dimensions of psychopathology assessed using the Structured Clinical Interview for DSM-5 (SCID). Int J Methods Psychiatr Res 27:
McAnany, J Jason; Park, Jason C (2018) Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy. Invest Ophthalmol Vis Sci 59:2652-2658

Showing the most recent 10 out of 28 publications