Overall: Institute of Translational Health Sciences The Institute of Translational Health Sciences (ITHS) is dedicated to speeding science to the clinic for the benefit of patients and communities throughout Washington, Wyoming, Alaska, Montana, and Idaho. Since 2007, we have worked with our partners?the University of Washington (UW), Seattle Children's, and the Fred Hutchinson Cancer Research Center (Fred Hutch)?to develop our hub as a catalyst for high-quality clinical and translational research in our five-state region and across the nation. Our past progress has focused on developing and providing resources, education, and expertise for investigators in our region, thereby creating critical community collaborations to establish a research-ready community, develop partnerships with our regional universities, and build the infrastructure for a learning healthcare system. As a result, we are well positioned to create a seamless interface between the clinical and research arms of our institutions, and also to increase the pipeline of underrepresented minority students and faculty in translational science. In the next five years, we will transform our education programs into a virtual clinical and translational science college that will provide directed education to improve the quality of research in our region. Our work will include systematic review of existing programs to ensure all elements of successful approaches to adult education are represented, guarantee accessibility across our region, and ensure development of new areas of scholarship. We will also further develop lasting local, regional, and national collaborations that are project- based and instill a culture of collaboration that results in measurable health impacts for our communities. This impact will be achieved by accelerating the development of new collaborations, providing a focus on dissemination of health innovation, and a more complete integration of our longstanding community partners into the governance of the ITHS. In addition, we will work to ensure, through newly developed collaborations, that every patient has access to participate in research, whether urban or rural, at the extreme of the lifespan, or a member of one of the rapidly growing minority populations in the Pacific Northwest. We are leaders in the Toyota Production System Lean Continuous Process Improvement, and we will work to continue to transform the institutions in the region to conduct research more efficiently and with higher quality. We will expand on these efforts to develop training for our partners in the region, and nationally so that the Pacific Northwest will be the leader in conducting research better, faster, and cheaper. Finally, we will create common and communicating informatics platforms across our partner institutions and regional partners that will be the basis of a ?learning healthcare system? in our region. Our work will include implementation of a cross- institutional clinical trials management system, development of a federated central portal and cohort discovery engine, deployment of an integrated self-service research data access tool, and enhanced regional access to electronic data capture tools via the Northwest Regional Medical Library.

Public Health Relevance

Housed at the University of Washington, the Institute of Translational Health Sciences has established our hub as a catalyst for high-quality clinical and translational research. We are a model for how multi-institutional collaboration can advance scientific discovery. We unite three major research institutions and a broad five- state region under the shared vision of speeding scientific discoveries to clinical practice to benefit the health and well-being of individuals throughout our region and beyond.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR002319-05
Application #
10118251
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Rubio, Mercedes
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
5
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Gómez, Laurén A; Crowell, Claudia S; Njuguna, Irene et al. (2018) Improved Neurodevelopment After Initiation of Antiretroviral Therapy in Human Immunodeficiency Virus-infected Children. Pediatr Infect Dis J 37:916-922
Harlow, Kathryn E; Africa, Jonathan A; Wells, Alan et al. (2018) Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease. J Pediatr 198:76-83.e2
Liese, Angela D; Ma, Xiaonan; Ma, Xiaoguang et al. (2018) Dietary quality and markers of inflammation: No association in youth with type 1 diabetes. J Diabetes Complications 32:179-184
Glick, Sara Nelson; Burt, Richard; Kummer, Kim et al. (2018) Increasing methamphetamine injection among non-MSM who inject drugs in King County, Washington. Drug Alcohol Depend 182:86-92
Cole, Allison M; Pflugeisen, Bethann; Schwartz, Malaika R et al. (2018) Cross sectional study to assess the accuracy of electronic health record data to identify patients in need of lung cancer screening. BMC Res Notes 11:14
Putcha, Nirupama; Paul, Gabriel G; Azar, Antoine et al. (2018) Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS. PLoS One 13:e0194924
West, Natalie E; Goss, Christopher H; Nichols, David P (2018) The Long and the Short of It in Cystic Fibrosis Clinical Research Outcomes. Ann Am Thorac Soc 15:430-431
Middleton, Michael S; Van Natta, Mark L; Heba, Elhamy R et al. (2018) Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease. Hepatology 67:858-872
Wilfond, Benjamin S; Porter, Kathryn M; Creevy, Kate E et al. (2018) Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective. Am J Bioeth 18:64-65
Ketterl, Tyler G; Chow, Eric J; Leisenring, Wendy M et al. (2018) Adipokines, Inflammation, and Adiposity in Hematopoietic Cell Transplantation Survivors. Biol Blood Marrow Transplant 24:622-626

Showing the most recent 10 out of 316 publications