Contact PD/PI: Evanoff, Bradley A Overall Component 7. Project Summary/Abstract: The Washington University (WU) Institute of Clinical and Translational Sciences (ICTS) has transformed clinical and translational science and research education in our region, and fostered productive scientific collaborations with our hub partner institutions University of Missouri-Columbia, Saint Louis University, St. Louis College of Pharmacy, BJC HealthCare, Barnes Jewish Hospital, and St. Louis Children's Hospital. The ICTS now proposes innovative aims that align well with the goals of the CTSA network, and will together catalyze discovery and advance research findings into real-world implementation to improve health and health care. 1. Provide interdisciplinary programs to develop, promote, and retain highly qualified and diverse faculty, trainees, and staff who can translate scientific discoveries into action. We will tailor our efforts to the needs of individuals, promote formation of transdisciplinary, inter-institutional, and inter-hub teams, rigorously assess our programs, and draw on our institutional and regional strengths in genomics, dissemination and implementation, and entrepreneurship. WORKFORCE DEVELOPMENT 2. Facilitate research that is designed for implementation by engaging diverse communities and stakeholders in collaborative teams at all stages of the translational research process. We will partner with patient advocates, propel the science of community and stakeholder engagement, break down barriers to allow integration of research findings into clinical practice, and capitalize on our local entrepreneurial ecosystem to apply discoveries to improve community health. COLLABORATION AND ENGAGEMENT 3. Integrate research across the lifespan and promote translational science within complex populations. The ICTS will address health disparities and differences in disease manifestations across different ages and among special populations, address both urban and rural populations, catalyze formation of transdisciplinary teams, and evaluate the clinical, community, and entrepreneurial outcomes of our researchers' work. INTEGRATION 4. Drive innovation, quality, and efficiency in the translational research, by using best practices and streamlined institutional processes to support high quality multi-center clinical trials and developing new methodological approaches to facilitate translational research. METHODS AND PROCESSES 5. Apply innovative informatics solutions to improve quality and efficiency at every stage of translational research, and create an ecosystem that integrates diverse data and facilitates the interoperability, use, and reuse of digital assets. INFORMATICS Successful completion of these aims will transform regional research, dissemination, and workforce development and will apply the considerable resources of WU and its partners to national CTSA goals to advance clinical and translational science and improve human health. Project Summary/Abstract Page 375 Contact PD/PI: Evanoff, Bradley A Overall Component 8.

Public Health Relevance

The overall goal of this grant is to accelerate advances in human health by engaging multiple stakeholders in the translation of scientific discoveries to drive improvements in health among diverse populations. Our proposal will improve clinical research through high quality and efficient methods/processes, develop a trained workforce skilled in team science, and disseminate research findings into real-world implementation to improve health and health care for patients, communities, and our nation. Project Narrative Page 376

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR002345-01
Application #
9474890
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Purucker, Mary E
Project Start
2017-06-19
Project End
2022-02-28
Budget Start
2017-06-19
Budget End
2018-02-28
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Kelsey, Megan M; Braffett, Barbara H; Geffner, Mitchell E et al. (2018) Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab 103:2309-2318
Bittel, Adam J; Bohnert, Kathryn L; Reeds, Dominic N et al. (2018) Reduced Muscle Strength in Barth Syndrome May Be Improved by Resistance Exercise Training: A Pilot Study. JIMD Rep :
Yarbrough, Chester K; Bommarito, Kerry M; Gamble, Paul G et al. (2018) Population-based approaches to treatment and readmission after spinal cord injury. J Neurosurg Sci 62:107-115
Lam, Wing Y; Jash, Arijita; Yao, Cong-Hui et al. (2018) Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function. Cell Rep 24:2479-2492.e6
Lin, Huawen; Guo, Suyang; Dutcher, Susan K (2018) RPGRIP1L helps to establish the ciliary gate for entry of proteins. J Cell Sci 131:
Yannascoli, Sarah M; Stwalley, Dustin; Saeed, Mohammed J et al. (2018) A Population-Based Assessment of Depression and Anxiety in Patients With Brachial Plexus Injuries. J Hand Surg Am 43:1136.e1-1136.e9
Olfson, Emily; Bloom, Joseph; Bertelsen, Sarah et al. (2018) CYP2A6 metabolism in the development of smoking behaviors in young adults. Addict Biol 23:437-447
Zhang, Yiming; Higgins, Cassandra B; Mayer, Allyson L et al. (2018) TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose. Autophagy 14:1959-1975
Burnham, Jason P; Kollef, Marin H (2018) qSOFA score: Predictive validity in Enterobacteriaceae bloodstream infections. J Crit Care 43:143-147
Raymer, David S; Moreno, Jonathan D; Sintek, Marc A et al. (2018) The Combination of Tricuspid Annular Plane Systolic Excursion and HeartMate Risk Score Predicts Right Ventricular Failure After Left Ventricular Assist Device Implantation. ASAIO J :

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