The University of Wisconsin (UW) Institute for Clinical and Translational Research (ICTR) was created in 2007 against a backdrop of institutional change at UW during which the UW Medical School pivoted to become a School of Medicine and Public Health (SMPH, 2005) and the other Health Sciences Schools retooled their missions to encompass health maintenance, preventative care, and improvements in health-delivery systems. Since its inception, ICTR succeeded in changing the culture of research at UW and at Marshfield Clinic (MC) and became recognized as the academic and administrative home for clinical and translational science. This section outlines the most notable ICTR accomplishments leading to transformative changes in the broad areas of administration, education of the translational workforce, and expansion of the research infrastructure. Many of the administrative successes were aligned with development of mutually- beneficial, collaborative relationships including the foundational UW and MC partnership, establishment of multi-site research networks, cross-CTSA program development, braided federal and local funding for ICTR programs and pilot awards, and affiliation with other UW centers and programs with overlapping missions. Translational workforce development included creating vigorous TL1 and KL2 training programs, establishing graduate degree and certificate programs in Clinical Investigation, and offering diverse non-degree options for learners at multiple levels and tracks. Additional collaborative efforts led to a nationally recognized program in research mentor training and the Health Equity Leadership Institute, a career development experience for investigators engaged in health disparities/health equity research. The central fact illustrating the expansion of the UW research infrastructure is that ICTR resources and services supported ~2,500 unique investigators, who have pursued 3,824 research projects. ICTR has provided pilot funding across the T0-T4 translational spectrum including awards specific to pediatric, geriatric, and minority populations. Consultations and other expert services span biostatistics, bioinformatics, laboratory services, and an array of clinical and regulatory services. Finally, the ICTR community engagement program is recognized as a national model for how to create partnerships with community stakeholders and organizations (431 to date) and now includes dissemination and implementation programs. Significantly, this section also provides examples of how ICTR- supported research programs have already impacted health care and health in Wisconsin and nationally. In the next grant cycle, ICTR will continue to address translational workforce development with an emphasis on team science and competency-based training, and community engagement in research with novel strategies for implementation of health advances and involvement of patient advocates. Additionally, the research infrastructure will be continuously improved through cycles of quality improvement and innovation and informatics methods for translational research will be introduced. Special populations research will be integrated across the T0-T4 spectrum and across the lifespan. Project Summary/Abstract Page 126 Contact PD/PI: DREZNER, MARC K Overall - CTSA As a member of the NIH Clinical and Translational Science Awards program since 2007, the mission of the University of Wisconsin (UW) Institute for Clinical and Translational Research (ICTR) is to improve public health by translating basic research discoveries into direct, practical improvements in clinical care and health care delivery systems. Current ICTR-supported research programs have already directly impacted community health in Wisconsin and nationally. ICTR represents a partnership of five UW Health Sciences Schools and Marshfield Clinic who work synchronously to improve research infrastructure, enhance local and multisite collaborative research networks, engage patient advocates and community stakeholders in research, and train the future clinical and translational research workforce.
Page 127 Contact PD/PI: DREZNER, MARC K RESOURCES OVERVIEW: The University of Wisconsin Institute for Clinical & Translational Research (ICTR) is a partnership between the Schools of Medicine & Public Health, Nursing, Pharmacy, Veterinary Medicine, and the College of Engineering at the UW-Madison campus, and Marshfield Clinic, a private non-profit, health-care organization in Marshfield, Wisconsin. The main UW-Madison campus encompasses 936 acres with an additional 9,647 acres of off- campus properties, including an arboretum and experimental farms. UW-Madison has about 3.82 million square feet of building space dedicated to research. The campus also has ~2.3 million square feet for academic support, including that to house support staff for the research mission, and ~1.0 million square feet of hospital space. The main Marshfield medical complex consists of four components including Marshfield Clinic, Marshfield Clinic Research Foundation (MCRF), Marshfield Laboratories, and St. Joseph's Hospital (a 524-bed acute care facility). In addition, Marshfield Clinic encompasses 52 regional clinics serving northern, central, and western Wisconsin, and the Upper Peninsula of Michigan. MCRF research laboratories are divided between state-of- the-art facilities in the Lawton Center (total square footage: 54,000 sq. ft.) and the Laird Center (total square footage: 52,000 sq. ft. for Laird South and 106,000 sq ft for Laird North). Laird South and Laird North are linked to the Lawton Center by a skywalk. FACILITES: In Madison, ICTR executive offices, 4,250 square feet, are located in the Health Sciences Learning Center (HSLC) on the west end of the main campus. The HSLC is situated near several key research buildings and the UW Health Sciences Schools & College of Engineering. Multiple research facilities and buildings contiguous with or close to the HSLC provide state of the art technology and research space. Much of the ICTR space acquired over time is located in the contiguous buildings. Occupants of the buildings include: Yr Space (Sq Ft) Site/Function Space (Sq Ft) 2008 4,250 6,300 2,000 HSLC Administration UW HC CRU UWHC OCT Offices 12,550 2009 1,000 HSLC CCHE Administration 13,550 2010 7,500 1,300 1,750 UBOB Community Engagement UBOB OCT Offices UBOB IRB Offices 23,800 2012 1,000 HSLC Administration 24,100 2013 750 400 HSLC IT Offices COB Server Space 25,250 2014 1,500 HSLC Administration 26,750 CRU: Clinical Research Unit; OCT: Office of Clinical Trials; COB: Centennial Office Building; UWHC: UW Hospital & Clinics; UBOB: University Bay Office Building; HSLC: Health Science Learning Center; IT: Information Technology ? School of Medicine & Public Health (SMPH) located in the HSLC ? UW Hospital and Clinical Sciences Center (CSC) adjoining the HSLC ? School of Nursing (SON) located in a building across the street from the HSLC ? Wisconsin Institutes for Medical Research (WIMR), Towers I-III, adjoining the HSLC ? School of Pharmacy located in Rennebohm Hall adjoining the HSLC by a connecting bridge ? American Family Children?s Hospital (AFCH) adjoining the CSC by a connecting bridge ? William S. Middleton Memorial Veterans Hospital (VA HOSP) adjoining the CSC ? Waisman Center across from the AFCH ? Wisconsin Alumni Research Foundation (WARF), 0,25 miles east of the HSLC ? School of Veterinary Medicine (SVM), 0.5 miles east of the HSLC ? College of Engineering (COE), 1.0 miles east of the HSLC ? Wisconsin Institutes for Discovery (WID), 1.5 miles east of the HSLC ? Morgridge Institute for Research, 1.5 miles east of the HSLC, adjoining the WID ? Wisconsin State Laboratory of Hygiene. 1.5 miles east of the HSLC ? Wisconsin National Primate Research Center, 2.0 miles southeast of the HSLC ? Meriter Hospital located 2.5 miles southeast of the HSLC on Park Street Facilities & Other Resources Page 128
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