GHESKIO is a Haitian organization dedicated to research, service, and training in HIV/AIDS with a 37 year track record of NIH-funded clinical research. GHESKIO has two clinical sites in Port au Prince, Haiti. The Downtown site has large HIV/TB clinics, a maternal child health center, a cardiovascular center, and programs in adjacent slums. The North site has HIV/TB clinics, an MDR-TB hospital, and a BSL3 TB laboratory. The GHESKIO Clinical Trials Unit (CTU) has two clinical research sites (CRSs) enrolling male and female participants across the lifespan, including pregnant women, infants, children, adolescents and adults. The GHESKIO CTU will continue to participate in two networks: Adult HIV/AIDS Therapeutic Trials (ACTG) and Maternal, Adolescent, Pediatric therapeutics (IMPAACT). We propose the following three aims: 1. Operate a single organization (GHESKIO) CTU with two research sites that is integrated, cohesive, and able to respond rapidly to a breadth of emerging research priorities. The CTU will maximize efficiency by having a single research component for administration, communication, evaluation, community liaison, data management, regulatory assurance, quality management, and training program. Each CRS has its own pharmacy. The main laboratory is at GHESKIO-North and the downtown site has a satellite laboratory. 2. Conduct adult HIV/AIDS therapeutic trials at GHESKIO-Downtown and GHESKIO-North - ACTG: Haiti has the highest HIV prevalence in the hemisphere with 2.0% of adults HIV infected. Both GHESKIO sites (Downtown, North) have large HIV-infected adult ART nave and ART-experienced cohorts available for recruitment into trials. Haiti also has the highest rates of TB with a prevalence of 1,066/100,000 in Port au Prince. GHESKIO treats ~ 2,000 TB patients annually including patients with MDR-TB who are available for enrollment into TB treatment trials. GHESKIO has established a new cardiovascular disease research unit to study the chronic complications of HIV. 3. Conduct maternal, adolescent, and pediatric HIV/AIDS trials at GHESKIO-Downtown- IMPAACT: GHESKIO-Downtown has the expertise, research capacity, and populations for trials of new antiretroviral drugs in children, adolescents and pregnant women. GHESKIO pediatricians identify and enroll HIV-infected newborns for trials of intensive therapy to induce an ART free remission. GHESKIO investigators are leaders in PK studies of TB drugs in children and pregnant women. We will be leading a trial evaluating one month isoniazid/rifapentine prophylaxis in pregnant women. GHESKIO will introduce studies on nutritional interventions in pregnant women and newborns to improve their growth and neurologic development.
GHESKIO is a Haitian organization dedicated to research, service, and training in HIV/AIDS with a 37 year track record of NIH-funded clinical research. The GHESKIO Clinical Trials Unit has two clinical research sites in Port au Prince and will conduct research in two NIAID networks: The adult HIV/AIDS therapeutic clinical trials group and the maternal-adolescent-pediatric HIV/AIDS trials group. The goal is to improve the treatment of HIV, tuberculosis, and HIV complications across the lifespan in pregnant women, adolescents, children, and adults of all ages in Haiti and around the world.
|Batavia, Ashita S; Severe, Patrice; Lee, Myung Hee et al. (2018) Blood pressure and mortality in a prospective cohort of HIV-infected adults in Port-au-Prince, Haiti. J Hypertens 36:1533-1539|
|Carriquiry, Gabriela; Giganti, Mark J; Castilho, Jessica L et al. (2018) Virologic failure and mortality in older ART initiators in a multisite Latin American and Caribbean Cohort. J Int AIDS Soc 21:e25088|
|Dananché, Cédric; Sánchez Picot, Valentina; Bénet, Thomas et al. (2018) Burden of Influenza in Less Than 5-Year-Old Children Admitted to Hospital with Pneumonia in Developing and Emerging Countries: A Descriptive, Multicenter Study. Am J Trop Med Hyg 98:1805-1810|
|Swindells, S; Gupta, A; Kim, S et al. (2018) Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). Int J Tuberc Lung Dis 22:1016-1022|
|Guiteau Moise, Colette; Rivera, Vanessa R; Hennessey, Kelly A et al. (2018) A Successful Model of Expedited Antiretroviral Therapy for Clinically Stable Patients Living With HIV in Haiti. J Acquir Immune Defic Syndr 79:70-76|
|Caro-Vega, Yanink; Belaunzarán-Zamudio, Pablo F; Crabtree-Ramírez, Brenda E et al. (2018) Durability of Efavirenz Compared With Boosted Protease Inhibitor-Based Regimens in Antiretroviral-Naïve Patients in the Caribbean and Central and South America. Open Forum Infect Dis 5:ofy004|
|Caro-Vega, Y; Belaunzarán-Zamudio, P F; Crabtree-Ramírez, B et al. (2018) Trends in proportion of older HIV-infected people in care in Latin America and the Caribbean: a growing challenge. Epidemiol Infect 146:1308-1311|
|McNairy, Margaret L; Joseph, Patrice; Unterbrink, Michelle et al. (2017) Outcomes after antiretroviral therapy during the expansion of HIV services in Haiti. PLoS One 12:e0175521|
|Rivera, V R; Jean-Juste, M-A; Gluck, S C et al. (2017) Diagnostic yield of active case finding for tuberculosis and HIV at the household level in slums in Haiti. Int J Tuberc Lung Dis 21:1140-1146|
|Bristow, Claire C; Lee, Sung-Jae; Severe, Linda et al. (2017) Attributes of diagnostic tests to increase uptake of dual testing for syphilis and HIV in Port-au-Prince, Haiti. Int J STD AIDS 28:259-264|
Showing the most recent 10 out of 69 publications