Sub-Saharan Africa continues to bear a disproportionate burden of the global HIV epidemic. Conducting studies in the most affected areas of the world is critical to the international HIV research agenda. The Johns Hopkins University-Blantyre Clinical Trials Unit (JHU Blantyre-CTU) and its clinical research site (CRS) in Malawi, located in one of the most affected regions of the world, propose to continue and expand high impact research collaborations with four NIAID Clinical Research Networks in order to prevent, treat and manage HIV and AIDS in adults, couples and children. With more than 20 years of HIV research experience and the strong backing of the host institution, Johns Hopkins University, the CTU and CRS leadership will be responsible for the coordination and execution of clinical trials at the Blantyre CRS in accordance with all Network, NIAID and regulatory policies. The CTU aims to advance the scientific agenda of the proposed Clinical Research Networks by generating and developing new scientific concepts; continuing implementation of the active study protocols at the CRS in Blantyre under the current CTU; and by having the capacity and processes in place to quickly engage protocol-specific research sites to respond to emerging Network needs. The CTU will emphasize quality, oversight, cohesiveness and efficiency in all operations as it works to achieve these aims. Currently, the Blantyre CRS is involved in 26 studies at various stages, from initiation to completion, for four existing Divisionof AIDS/NIAID Clinical Research Networks. The CRS has established effective collaborations and engaged constituents representing the needs and research priorities of the local communities through the use of Community Advisory Group. The goal of this application is to describe scientific, leadership and administrative strengths of the proposed JHU-Blantyre CRS which will ensure successful implementation of the NIAID international clinical research agenda. The ten components of this application provide a scientific overview of the proposed CTU and describe its administrative and financial management structures; plans for communication and evaluation; and the personnel and resources of each technical department of the Blantyre CRS, including community engagement, pharmacy, laboratory, quality and regulatory assurance, and data management.
The proposed Johns Hopkins University-Blantyre Clinical Trials Unit (CTU) and its Clinical Research Site (CRS) in Blantyre, Malawi have the expertise, experience, infrastructure and commitment to contribute to the scientific agendas of four NIAID Clinical Research Networks. Over the past 20 years, including 6 years in the current CTU cycle, the CRS has built strong relationships with the community to ensure access to appropriate study populations. The CTU Principal Investigator is strongly supported by the host institution, the Johns Hopkins University through its leadership and wide array of research-related resources.
|Palanee-Phillips, Thesla; Roberts, Sarah T; Reddy, Krishnaveni et al. (2018) Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial. J Acquir Immune Defic Syndr 79:580-589|
|Hosseinipour, Mina C; Kang, Minhee; Krown, Susan E et al. (2018) As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial. Clin Infect Dis 67:251-260|
|Robertson, K; Oladeji, B; Jiang, H et al. (2018) HIV-1 and TB Co-infection in Multinational Resource Limited Settings: Increased neurological dysfunction. Clin Infect Dis :|
|Ngongondo, McNeil; Miyahara, Sachiko; Hughes, Michael D et al. (2018) Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. J Acquir Immune Defic Syndr 78:54-61|
|Flynn, Patricia M; Taha, Taha E; Cababasay, Mae et al. (2018) Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1-Infected Women With High CD4 Cell Count (IMPAACT PROMISE): A Randomi J Acquir Immune Defic Syndr 77:383-392|
|Robertson, Kevin R; Jiang, Hongyu; Kumwenda, Johnstone et al. (2018) HIV Associated Neurocognitive Impairment in Diverse Resource Limited Settings. Clin Infect Dis :|
|Fowler, Mary G; Flynn, Patricia; Aizire, Jim (2018) What is new in perinatal HIV prevention? Curr Opin Pediatr 30:144-151|
|Palumbo, Philip J; Fogel, Jessica M; Hudelson, Sarah E et al. (2018) HIV Drug Resistance in Adults Receiving Early vs. Delayed Antiretroviral Therapy: HPTN 052. J Acquir Immune Defic Syndr 77:484-491|
|Greer, Amy E; Ou, San-San; Wilson, Ethan et al. (2017) Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052. J Acquir Immune Defic Syndr 76:388-393|
|Bisson, Gregory P; Ramchandani, Ritesh; Miyahara, Sachiko et al. (2017) Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults. AIDS 31:2217-2225|
Showing the most recent 10 out of 50 publications