ICAC's goal is to include further development of cockroach allergen immunotherapy and consideration of new allergen immunotherapies;for example to mouse allergens;the development and execution of clinical and mechanistic studies targeted to inner-city asthma phenotypes, and interventions designed to prevent the incidence of asthma or its progression. In addition, the URECA birth cohort study will be continued to the end of the grant, when the participants will range from 14 to 16 years of age, with the goal to provide information on the immunologic basis of late childhood and adolescence-onset asthma, as well as the remission of asthma during the same years.
ICAC is a multi-study, multi-center initiative to study the causes of the urban asthma epidemic that afflicts millions of children and to develop treatments to improve control of asthma in this population and for children in general.
|Durack, Juliana; Huang, Yvonne J; Nariya, Snehal et al. (2018) Bacterial biogeography of adult airways in atopic asthma. Microbiome 6:104|
|Durack, Juliana; Boushey, Homer A; Huang, Yvonne J (2018) Incorporating the airway microbiome into asthma phenotyping: Moving toward personalized medicine for noneosinophilic asthma. J Allergy Clin Immunol 141:82-83|
|Sorkness, Ronald L; Zoratti, Edward M; Kattan, Meyer et al. (2018) Obstruction phenotype as a predictor of asthma severity and instability in children. J Allergy Clin Immunol 142:1090-1099.e4|
|Moore, Eugene; Grifoni, Alba; Weiskopf, Daniela et al. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA. Hum Immunol 79:821-822|
|Gill, Michelle A; Liu, Andrew H; Calatroni, Agustin et al. (2018) Enhanced plasmacytoid dendritic cell antiviral responses after omalizumab. J Allergy Clin Immunol 141:1735-1743.e9|
|Schulten, Véronique; Westernberg, Luise; Birrueta, Giovanni et al. (2018) Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma. Front Immunol 9:235|
|Glesner, Jill; Filep, Stephanie; Vailes, Lisa D et al. (2018) Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine in vitro extract potency for IgE reactivity. J Allergy Clin Immunol :|
|da Silva Antunes, Ricardo; Pham, John; McMurtrey, Curtis et al. (2018) Urinary Peptides As a Novel Source of T Cell Allergen Epitopes. Front Immunol 9:886|
|Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866|
|Dhanda, Sandeep Kumar; Karosiene, Edita; Edwards, Lindy et al. (2018) Predicting HLA CD4 Immunogenicity in Human Populations. Front Immunol 9:1369|
Showing the most recent 10 out of 37 publications