We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project;consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive;341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer;strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer;and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.

Public Health Relevance

The goal of this proposal is to continue the follow-up of HPFS, the only large cohort of men with biomarkers and repeated measures of diet, physical activity, and other exposures over several decades, now in a maximally informative phase and is a unique resource for scientific aims that integrate diet and other environmental variables, biomarkers, genetic predisposition and mediating variables in relation to cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1CA167552-01
Application #
8298342
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (J1))
Program Officer
Mahabir, Somdat
Project Start
2012-08-21
Project End
2017-06-30
Budget Start
2012-08-21
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$2,401,098
Indirect Cost
$831,869
Name
Harvard University
Department
Nutrition
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Wu, Juan; Wilson, Kathryn M; Stampfer, Meir J et al. (2018) A 24-year prospective study of dietary ?-linolenic acid and lethal prostate cancer. Int J Cancer 142:2207-2214
Petrick, Jessica L; Campbell, Peter T; Koshiol, Jill et al. (2018) Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. Br J Cancer 118:1005-1012
Hu, Yang; Ding, Ming; Yuan, Chen et al. (2018) Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology 154:916-926.e9
Lopez, David S; Liu, Lydia; Rimm, Eric B et al. (2018) Coffee Intake and Incidence of Erectile Dysfunction. Am J Epidemiol 187:951-959
Graff, Rebecca E; Cho, Eunyoung; Preston, Mark A et al. (2018) Dietary Acrylamide Intake and Risk of Renal Cell Carcinoma in Two Large Prospective Cohorts. Cancer Epidemiol Biomarkers Prev 27:979-982
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Grasso, Catherine S; Giannakis, Marios; Wells, Daniel K et al. (2018) Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov 8:730-749
Liu, Li; Tabung, Fred K; Zhang, Xuehong et al. (2018) Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol 16:1622-1631.e3
Theofylaktopoulou, Despoina; Midttun, Øivind; Ueland, Per M et al. (2018) Impaired functional vitamin B6 status is associated with increased risk of lung cancer. Int J Cancer 142:2425-2434
O'Reilly, Éilis J; Bjornevik, Kjetil; Schwarzschild, Michael A et al. (2018) Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 19:194-200

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