African-American adolescent females recently discharged from youth detention centers have a high prevalence of HIV-associated social, psychological and behavioral risk factors. There are, however, no evidence-based interventions (EBI) for this vulnerable population. To address this gap, the proposed study is an exciting opportunity to build upon a link established over the past four years between the Rollins School of Public Health and the Georgia Department of Juvenile Justice to harness the multidisciplinary expertise and experience and of our research team to adapt a CDC-defined EBI, called ? SiHLE. The proposed study will be conducted in three stages: (1) Adaptation, (2) Implementation, and (3) Evaluation. In Stage 1, Adaptation, we will use a coordinated and systematically guided adaptation process based on our ADAPT-ITT framework to adapt SiHLE to enhance its appropriateness and efficacy for African American adolescent females recently discharged from a youth detention center. In Stage 2, Implementation, we propose to implement the adapted SiHLE intervention using a Phase III randomized controlled trial with a sample of 350 unmarried African-American ? adolescent females, 13-17 years of age, recruited at the Metro Regional Youth Detention Center (RYDC), in Atlanta, Georgia. Upon discharge, adolescents will be contacted and invited to participate in the proposed study. Eligible adolescents will be scheduled to attend our project site, conveniently located in downtown Atlanta (Citizens Trust Building), to complete baseline procedures. All adolescents will be required to have written informed parental/guardian consent and complete signed assent forms. ? Adolescents will complete a baseline audio computer-assisted interview (ACASI) assessment. The ACASI is derived from Social Cognitive Theory and the Theory of Gender and Power, the same theoretical framework underlying the original SiHLE intervention. The ACASI is designed to assess adolescents' HIV-associated sexual and substance use behaviors, and other important mediators and moderators of HIV-risk and preventive behaviors. Subsequently, adolescents will be randomized to receive either the adapted SiHLE intervention or a time-equivalent health promotion condition. ? Adolescents in each study arm complete 4 group sessions on consecutive Saturdays implemented by an African American health educator and co-facilitated by trained African American peer educators. In Stage 3, Evaluation, adolescents will be re-contacted to complete post-intervention ACASI assessments at 3-, 6-, and 12-month follow-up. An intent-to-treat analysis, using linear and logistic generalized estimating equations (GEE) analysis will examine the efficacy of the adapted SiHLE intervention, relative to the health promotion comparison condition, in enhancing HIV-preventive ? sexual behaviors and psychosocial mediators of safer sex over the 12-month follow-up period. ? ? ?

National Institute of Health (NIH)
National Center for HIV, Viral Hepatitis, STDS and Tb Prevention (NCHHSTP)
Prevention Intervention Research on Substance Abuse in Children Cooperative Agreements (UR6)
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Special Emphasis Panel (ZPS1-FXR (04))
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Stewart, Barbara
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Emory University
Schools of Public Health
United States
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Seth, Puja; Raiford, Jerris; DiClemente, Ralph J (2016) Factors Associated with HIV Testing among African American Female Adolescents in Juvenile Detention Centers. AIDS Behav 20:2010-3
Gray, Simone C; Holmes, Kristin; Bradford, Denise R (2016) Factors Associated with Pregnancy among Incarcerated African American Adolescent Girls. J Urban Health 93:709-18
Davis, Teaniese L; Boyce, Lorin S; Rose, Eve et al. (2016) Lessons Learned From Delivering Imara, an HIV/STI Risk Reduction Intervention for African American Girls in Juvenile Detention. Health Promot Pract 17:31-9
DiClemente, Ralph J; Davis, Teaniese L; Swartzendruber, Andrea et al. (2014) Efficacy of an HIV/STI sexual risk-reduction intervention for African American adolescent girls in juvenile detention centers: a randomized controlled trial. Women Health 54:726-49
Latham, Teaniese P; Sales, Jessica M; Renfro, Tiffaney L et al. (2012) Employing a teen advisory board to adapt an evidence-based HIV/STD intervention for incarcerated African-American adolescent women. Health Educ Res 27:895-903
Latham, Teaniese P; Sales, Jessica M; Boyce, Lorin S et al. (2010) Application of ADAPT-ITT: adapting an evidence-based HIV prevention intervention for incarcerated African American adolescent females. Health Promot Pract 11:53S-60S