Haplotype and linkage disequilibrium analysis has contributed to studies on recombination and human gene mapping. This project develops an algorithm to obtain maximum likelihood estimates haplotype frequencies, and develops a set of hypotheses that can be statistically tested in order to demonstrate pairwise and higher order linkage disequilibrium. A computer program was written to implement the methods. The utility of the methods and computer program is verified using Monte Carlo simulations. This work will be applicable to the many short tandem repeat DNA polymorphisms that our lab is typing for linkage analyses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000018-02
Application #
3745198
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code