This clinical protocol will examine measures of heart rate variability (HRV) in male and female alcoholics admitted for drinking cessation continuously and non-invasively. These measures will be compared and contrasted with HRV parameters studied in healthy comparison subjects. Inter-beat interval (IBI) will be measured in patients for 3 consecutive 96 hours periods every 7 days during the course of treatment. Coarse-graining spectral analysis (CGSA) will be utilized to simultaneously evaluate parasympathetic (PNS) and sympathetic (SNS) nervous system indicators, and a measure of signal complexity and variability.
|Karimullah, K; George, D T; DePetrillo, P B (2001) The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence. Eur J Pharmacol 427:227-33|
|DePetrillo, P B; Bennett, A J; Speers, D et al. (2000) Ondansetron modulates pharmacodynamic effects of ketamine on electrocardiographic signals in rhesus monkeys. Eur J Pharmacol 391:113-9|
|DePetrillo, P B; White, K V; Liu, M et al. (1999) Effects of alcohol use and gender on the dynamics of EKG time-series data. Alcohol Clin Exp Res 23:745-50|