Molecular Genetic Studies on Alcoholism in American Indians

Robin, R.

Abstract

To identify alcoholism risk genes, we are collecting and testing for linkage families from three different American Indian populations which are prevalent relatively homogenous and in which alcoholism is highly prevalent. This study also addresses the genetic epidemiology and psychiatric comorbidity of alcoholism in Indians using structured psychiatric interviews of subjects in large families. Two hundred Cheyenne Indians have been clinically evaluated and their cell lines immortalized. At Jemez Pueblo, data and cell lines have been collected for 200 subjects. A study on the Pima Indians is in progress, with 200 members from single family collected and a target family size of 600. A large panel of random polymorphic probes has been typed in Cheyenne alcoholics and controls and genetic linkage analysis is in progress for this group. An analysis of psychiatric comorbidity analysis in Cheyenne Indian alcoholic has been completed.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AA000281-03
• Application #: 3789541
• Support Year: 3
• Fiscal Year: 1992

Institution

• Name: National Institute on Alcohol Abuse and Alcoholism
• Country: United States

Publications

Landefeld, Clare C; Hodgkinson, Colin A; Spagnolo, Primavera A et al. (2018) Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry 8:72

Hong, L E; Yang, X; Wonodi, I et al. (2011) A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav 10:530-5

O'Malley, Stephanie S; Robin, Robert W; Levenson, Aryeh L et al. (2008) Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trial. Alcohol Clin Exp Res 32:1271-83

Ducci, F; Enoch, M-A; Hodgkinson, C et al. (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13:334-47

Robin, Robert W; Gottesman, Irving I; Albaugh, Bernard et al. (2007) Schizophrenia and psychotic symptoms in families of two American Indian tribes. BMC Psychiatry 7:30

Barnett, Jennifer H; Heron, Jon; Ring, Susan M et al. (2007) Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry 164:142-9

Oquendo, Maria A; Hastings, Ramin S; Huang, Yung-Yu et al. (2007) Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 64:201-8

Clarimon, Jordi; Gray, Rebecca R; Williams, Lindsey N et al. (2007) Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. Alcohol Clin Exp Res 31:546-54

Minzenberg, Michael J; Xu, Ke; Mitropoulou, Vivian et al. (2006) Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. Psychiatr Genet 16:117-24

Enoch, Mary-Anne; Schwartz, Lori; Albaugh, Bernard et al. (2006) Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet 141:599-607