Studies suggest that the pathophysiology of alcoholism may differ significantly between men and women. To explore this possibility, we have employed several pharmacological challenge paradigms to compare the behavioral and endocrine responses between male and female alcoholics. Preliminary analysis of our results show that the m-CPP gives rise to minimal behavioral effects in women. This corresponds to the responses obtained from Type I male alcoholics (late onset) demonstrated in a separate study. In contrast, none of the women experienced a m-CPP induced """"""""desire to drink"""""""" response demonstrated to occur in approximately 40% of the Type II (late onset) male alcoholics.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000286-05
Application #
3745245
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code