Age is an independent risk factor for NIDDM. A decline in insulin secretion and a decrease in insulin action occur as people age. This combination makes people more prone to develop NIDDM. A similar phenomenon occurs in Wistar rats. We are using the beta cells from Wistar rats in the aged colony at the GRC to study changes with insulin secretion. We found that mRNA for insulin is preferentially diminished in islets, with glucokinase and glucagon messages unaffected. Therefore, one can envision when a stress is put on the system so more insulin is required, diabetes could result. We are exploring what factors lead to this diminution of insulin message and the possibility that we can prevent or reverse it. We have found the GLP-1 can somewhat restore the number of cells that are again responsive.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000214-04
Application #
3745453
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Carlson, Olga D; David, Jehan D; Schrieder, Jessica M et al. (2007) Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. Metabolism 56:1444-51
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Meneilly, G S; McIntosh, C H; Pederson, R A et al. (2001) Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes. Diabetes Care 24:964-5
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Meneilly, G S; McIntosh, C H; Pederson, R A et al. (2001) Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes Care 24:1951-6

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