Regulation of Physiological Functions During Aging - Assessment of Primate

Roth, G S.

Abstract

This project is attempting to determine whether caloric modification of the diets of Rhesus and squirrel monkeys can affect aging rate as assessed by various physiological, biochemical and behavioral indices. Although it has been known for 60 years that reduced feeding extends lifespan, delays and reduces age-related diseases and slows overall aging rate in rodents and lower animals, relevance to primates (especially humans) has never been established. We are examining a battery of indices of aging, as well as acute metabolic effects, of caloric restriction in order to finally answer this question.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AG000304-09
• Application #: 5200296
• Support Year: 9
• Fiscal Year: 1995

Institution

• Name: National Institute on Aging
• Country: United States

Publications

Ottinger, Mary Ann; Mobarak, Mohammed; Abdelnabi, Mahmoud et al. (2005) Effects of calorie restriction on reproductive and adrenal systems in Japanese quail: are responses similar to mammals, particularly primates? Mech Ageing Dev 126:967-75

Mattison, Julie A; Black, Angela; Huck, Jennifer et al. (2005) Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiol Aging 26:1117-27

Roth, George S; Mattison, Julie A; Ottinger, Mary Ann et al. (2004) Aging in rhesus monkeys: relevance to human health interventions. Science 305:1423-6

Lane, Mark A; de Cabo, Rafael; Mattison, Julie et al. (2004) The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp Gerontol 39:897-902

Matochik, John A; Chefer, Svetlana I; Lane, Mark A et al. (2004) Age-related decline in striatal volume in rhesus monkeys: assessment of long-term calorie restriction. Neurobiol Aging 25:193-200

Zhu, Min; Miura, Junnosuke; Lu, Lucy X et al. (2004) Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol 39:1049-59

Lane, Mark A; Mattison, Julie A; Roth, George S et al. (2004) Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol A Biol Sci Med Sci 59:405-7

Zhu, Min; de Cabo, Rafael; Lane, Mark A et al. (2004) Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann N Y Acad Sci 1019:448-52

Smucny, D A; Allison, D B; Ingram, D K et al. (2004) Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol 30:161-173, 2001. J Med Primatol 33:48-54

De Cabo, R; Cabello, R; Rios, M et al. (2004) Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver. Exp Gerontol 39:297-304