Epidemiological studies have shown that mean blood pressure and the prevalence of hypertension both increase with age. A possible role for dietary sodium intake in the blood pressure increase in aging individuals has been documented, but little information is available concerning possible age-associated changes in circulating hormones that affect sodium transport across vascular smooth muscle. The present study assesses individual differences in levels of two circulating sodium-pump inhibiting hormones as predictors of age-associated changes in resting blood pressure. Morning supine blood pressure and endogenous ouabain and digoxin-like factor are measured in Baltimore Longitudinal Study on Aging participants who meet the inclusion criteria. The study also investigates possible differences in circulating sodium-pump inhibitors as a function of race and gender. Data supporting the hypothesis of a positive correlation between resting blood pressure and circulating sodium-pump inhibitors could lead to pharmacological and nonpharmacological intervention in hypertension focusing on sodium-pump inhibitors and their determinants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000607-03
Application #
3745518
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code