Abstract

In epidemiological and longitudinal studies, there are specific measurement and selection biases that can affect conclusions regarding the relationships between disease and aging. Previously, we presented preliminary studies examining the consistency and reliability of responses to the clinical health evaluation, and selection bias as it related to cardiovascular diseases. During this reporting period, we expanded the studies to include all BLSA men. In addition, we examined the comparability of healthy younger and older men when used for cross-sectional studies. Three studies will be reported: (1) reliability of responses in the health evaluation, (2) selection bias in prevalence of disease based on age at entry, and (3) comparability of healthy sixty and eighty year old men.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000631-01
Application #
3808942
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cappola, Anne R; Maggio, Marcello; Ferrucci, Luigi (2008) Is research on hormones and aging finished? No! Just started! J Gerontol A Biol Sci Med Sci 63:696-7
Bartali, Benedetta; Frongillo, Edward A; Guralnik, Jack M et al. (2008) Serum micronutrient concentrations and decline in physical function among older persons. JAMA 299:308-15
Houston, Denise K; Cesari, Matteo; Ferrucci, Luigi et al. (2007) Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 62:440-6
Ferrucci, Luigi; Alley, Dawn (2007) Obesity, disability, and mortality: a puzzling link. Arch Intern Med 167:750-1
Beck, Justine; Ferrucci, Luigi; Sun, Kai et al. (2007) Low serum selenium concentrations are associated with poor grip strength among older women living in the community. Biofactors 29:37-44
Frayling, Timothy M; Timpson, Nicholas J; Weedon, Michael N et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-94
Howard, Caitlin; Ferrucci, Luigi; Sun, Kai et al. (2007) Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol 103:17-20
Newby, P K; Maras, Janice; Bakun, Peter et al. (2007) Intake of whole grains, refined grains, and cereal fiber measured with 7-d diet records and associations with risk factors for chronic disease. Am J Clin Nutr 86:1745-53